2023 Highlights

...
Dr. Shen , Chen-Yang
Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer
Cell Reports Jan 23, 2024

Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its effectiveness depends on biomarkers that are not prec ...

...
Dr. Hu , Che-Ming (Jack)
Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement
Acta Biomaterialia Nov 23, 2023

Plasma membrane isolation is a foundational process in membrane proteomic research, cellular vesicle studies, and biomimetic nanocarrier dev ...

...
Dr. Chern , Yijuang
Galectin-3 aggravates microglial activation and tau transmission in tauopathy
Journal of Clinical Investigation Nov 23, 2023

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau) ...

...
Dr. Yang , Ruey-Bing (Ray)
Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition
International Journal of Biological Macromolecules Nov 21, 2023

PhoSL (Pholiota squarrosa Lectin) has an exceptional binding affinity for biomolecules with core-fucosylated N-glycans. This modification in ...

...
Dr. Yan , Yu-Ting
Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization
Cell Reports Nov 14, 2023

Differentiated cardiomyocytes (CMs) must undergo diverse morphological and functional changes during postnatal development. However, the mec ...

...
Dr. Hsieh , Patrick Ching-Ho
Gut butyrate-producers confer post-infarction cardiac protection
Nature Communications Nov 09, 2023

The gut microbiome and its metabolites are increasingly implicated in several cardiovascular diseases, but their role in human myocardial in ...

...
Dr. Hsieh , Patrick Ching-Ho
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
Circulation Oct 31, 2023

Background: Remuscularization of the mammalian heart can be achieved after cell transplantation of human induced pluripotent stem cell ...

...
Dr. Roffler , Steve R.
Interactions between nanoparticle corona proteins and the immune system
Current Opinion in Biotechnology Oct 16, 2023

The corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can inte ...

...
Dr. Lin , Yi-Ling
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Journal of Biomedical Science Oct 12, 2023

Background: Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SA ...

...
Dr. Chang , Yi-Cheng
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators
Nature Communications Sep 25, 2023

Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing en ...

Years