Dr. Chern, Yijuang
Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
Acta Neuropathologica Communications, Jun 25, 2021
Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s di ......
Dr. Tsai, Kevin
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing
Genes & Development, Jun 17, 2021
Previous work has demonstrated that the epitranscriptomic addition of m6A to viral transcripts can promote the replicati ......
Dr. Tang, Tang K.
Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position
Cells, Jun 09, 2021
Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain ......
Dr. Hu, Che-Ming (Jack)
Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation
Advanced Materials, Jun 07, 2021
The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biom ......
Dr. Shen, Chen-Yang
MiR-139 Modulates Cancer Stem Cell Function of Human Breast Cancer through Targeting CXCR4
Cancers , May 25, 2021
The C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in various cancer stem/progenitor cells via ......
Dr. Yang, Shi-Bing
Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway
eLife, May 21, 2021
In the postnatal brain, neurogenesis occurs only within a few regions, such as the hippocampal sub-granular zone (SGZ). ......
Dr. Cheng, Andrew Tai Ann
Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population
Translational Psychiatry, May 20, 2021
The search for susceptibility genes underlying the heterogeneous bipolar disorder has been inconclusive, often with irre ......
Dr. Li, Chia-Wei
Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
American Journal of Cancer Research, May 15, 2021
The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Th ......
Dr. Huang, Yi-Shuian
CPEB3-downregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice
Neuropsychopharmacology, May 03, 2021
Susceptibility or resilience to posttraumatic stress disorder (PTSD) depends on one's ability to appropriately adjus ......
Dr. Hsieh, Patrick Ching-Ho
Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer
Science Advances, Apr 23, 2021
The delivery of therapeutics through the circulatory system is one of the least arduous and less invasive inte ......