Dr. Chern, Yijuang
A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis
Movement Disorders, Dec 23, 2021
Background: Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansi ......
Dr. Yang, Kai-Chien
Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling
Gut , Dec 21, 2021
Background and objectives:
Liver fibrosis (LF) occurs following chronic liver injuries. Cur ......
Dr. Lee, Yu-Ru
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models
Journal of Clinical Investigation, Dec 15, 2021
Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysf ......
Dr. Roffler, Steve R.
Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice
Biomedicine & Pharmacotherapy, Dec 06, 2021
Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ......
Dr. Lee, Yungling Leo
Investigating Obesity-related Risk Factors for Childhood Asthma
Pediatric Allergy and Immunology, Dec 02, 2021
Background: We tested the hypothesis that multiple obesity-related risk factors (obesity, physical activity, cardio ......
Dr. Tarn, Woan-Yuh
Antisense Oligonucleotide-Based Therapy of Viral Infections
Pharmaceutics, Nov 26, 2021
Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine develo ......
Dr. Li, Chia-Wei
Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro
EBioMedicine, Nov 25, 2021
Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ......
Dr. Cheng, Ching-Feng
The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
Biomedicine & Pharmacotherapy, Nov 25, 2021
In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ......
Dr. Hu, Yu-Feng
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Nature Biomedical Engineering , Nov 22, 2021
Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ......
Dr. Tarn, Woan-Yuh
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia
iScience, Nov 19, 2021
Thrombocytopenia-absent radius (TAR) syndrome is caused by RBM8A insufficiency. We generated megakaryocyte-specific  ......