2021 Highlights

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Dr. Chern , Yijuang
A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis
Movement Disorders Dec 23, 2021

      Background: Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansi ...

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Dr. Yang , Kai-Chien
Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling
Gut Dec 21, 2021

        Background and objectives:  Liver fibrosis (LF) occurs following chronic liver injuries. Cur ...

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Dr. Lee , Yu-Ru
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models
Journal of Clinical Investigation Dec 15, 2021

Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysf ...

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Dr. Roffler , Steve R.
Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice
Biomedicine & Pharmacotherapy Dec 06, 2021

    Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ...

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Dr. Lee , Yungling Leo
Investigating Obesity-related Risk Factors for Childhood Asthma
Pediatric Allergy and Immunology Dec 02, 2021

    Background: We tested the hypothesis that multiple obesity-related risk factors (obesity, physical activity, cardio ...

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Dr. Tarn , Woan-Yuh
Antisense Oligonucleotide-Based Therapy of Viral Infections
Pharmaceutics Nov 26, 2021

    Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine develo ...

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Dr. Li , Chia-Wei
Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro
EBioMedicine Nov 25, 2021

    Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ...

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Dr. Cheng , Ching-Feng
The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
Biomedicine & Pharmacotherapy Nov 25, 2021

    In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ...

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Dr. Hu , Yu-Feng
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Nature Biomedical Engineering Nov 22, 2021

  Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ...

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Dr. Tarn , Woan-Yuh
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia
iScience Nov 19, 2021

    Thrombocytopenia-absent radius (TAR) syndrome is caused by RBM8A insufficiency. We generated megakaryocyte-specific  ...

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