Dr. Chern, Yijuang

A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis

Movement Disorders, Dec 23, 2021

      Background: Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansi ......

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Dr. Yang, Kai-Chien

Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling

Gut , Dec 21, 2021

        Background and objectives:  Liver fibrosis (LF) occurs following chronic liver injuries. Cur ......

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Dr. Lee, Yu-Ru

WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models

Journal of Clinical Investigation, Dec 15, 2021

Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysf ......

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Dr. Roffler, Steve R.

Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice

Biomedicine & Pharmacotherapy, Dec 06, 2021

    Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ......

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Dr. Lee, Yungling Leo

Investigating Obesity-related Risk Factors for Childhood Asthma

Pediatric Allergy and Immunology, Dec 02, 2021

    Background: We tested the hypothesis that multiple obesity-related risk factors (obesity, physical activity, cardio ......

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Dr. Tarn, Woan-Yuh

Antisense Oligonucleotide-Based Therapy of Viral Infections

Pharmaceutics, Nov 26, 2021

    Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine develo ......

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Dr. Li, Chia-Wei

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

EBioMedicine, Nov 25, 2021

    Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ......

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Dr. Cheng, Ching-Feng

The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning

Biomedicine & Pharmacotherapy, Nov 25, 2021

    In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ......

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Dr. Hu, Yu-Feng

Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats

Nature Biomedical Engineering , Nov 22, 2021

  Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ......

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Dr. Tarn, Woan-Yuh

The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

iScience, Nov 19, 2021

    Thrombocytopenia-absent radius (TAR) syndrome is caused by RBM8A insufficiency. We generated megakaryocyte-specific  ......

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