Dr. Lin, Yi-Ling
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.
PLoS Pathog., Dec 30, 2015
Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell d ......
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Dr. Yang, Pan-Chyr
Small-molecule, T315, Promotes CBL-dependent Degradation of EGFR via Y1045 Autophosphorylation.
Am J Respir Crit Care Med., Nov 19, 2015
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Dr. Chen, Chinpan
Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA.
Nature Comm., Nov 12, 2015
PmrA, an OmpR/PhoB family response regulator, manages genes for antibiotic resistance. Phosphorylation of OmpR/PhoB response regulator induc ......
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Dr. Shieh, Sheau-Yann
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Nucl. Acids Res., Nov 03, 2015
Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMp ......
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Dr. Yang, Pan-Chyr
MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.
Oncotarget., Nov 02, 2015
Melanoma differentiation-associated gene-9 (MDA-9)/Syntenin is a novel therapeutic target because it plays critical roles in cancer progress ......
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Dr. Shen, Chen-Yang
Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer.
Oncotarget., Oct 23, 2015
Metastatic spread of cancer cells portends a poor prognosis and mortality for lung cancer patients. Hypoxia-inducible factor-1α (HIF-1 ......
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Dr. Yang, Pan-Chyr
Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.
Oncotarget., Oct 19, 2015
Dysfunction of the mitochondria is well-known for being associated with cancer progression. In the present study, we analyzed the mitochondr ......
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Dr. Huang, Yi-Shuian
NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress.
Nucl. Acids Res., Oct 07, 2015
Non-selenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx or GPx7) is an oxidative stress sensor that modulates ......
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Dr. Shih, Chiaho
The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion.
PLoS Pathog., Oct 02, 2015
The Endosomal Sorting Complex Required for Transport (ESCRT) is an important cellular machinery for the sorting and trafficking of ubiquitin ......
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Dr. Shen, Chen-Yang
Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study.
BMJ., Sep 23, 2015
OBJECTIVE:
To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cu ......
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