2015 Highlights

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Dr. Liu , Fu-Tong
Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling.
Journal of Investigative Dermatology Sep 22, 2015

Galectin-7, a member of the β-galactoside-binding protein family, is primarily expressed in stratified epithelial cells, including kera ...

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Dr. Hsieh , Patrick Ching-Ho
Nanoparticle distribution during systemic inflammation is size-dependent and organ-specific.
Nanoscale. Sep 11, 2015

This study comprehensively investigates the changing biodistribution of fluorescent-labelled polystyrene latex bead nanoparticles in a mouse ...

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Dr. Hung , Shih Chieh
Allo-transplantation of Mesenchymal Stem Cells Attenuates Hepatic Injury through IL1Ra Dependent Macrophage Switch in a Mouse Model of Liver Disease.
J Hepatol. Aug 11, 2015

Autologous transplantation of mesenchymal stem cells (MSCs) reduces concanavalin A (Con A)-induced hepatic injury in mice. However, the mech ...

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Dr. Chern , Yijuang
Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.
Hum. Mol. Genet. Aug 11, 2015

Huntington's disease (HD) is an autosomal dominant degenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (htt) ...

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Dr. Fann , Cathy S.-J.
Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.
Nat Commun. Jul 07, 2015

Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antithyroid drugs are the treatment corner ...

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Dr. Lin , Jung-Hsin
Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.
Nucleic Acids Res. Jul 06, 2015

Type II topoisomerases resolve topological problems of DNA double helices by passing one duplex through the reversible double-stranded break ...

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Dr. Chen , Yuan-Tsong
Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 Deficient Mice Reveals the Importance of Palmitoylation in Hair and Skin Differentiation.
J Invest Dermatol. Jun 29, 2015

Many biochemical pathways involved in hair and skin development have not been investigated. Here, we reported on the lesions and investigate ...

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Dr. Lin , Teng-Nan
PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription.
Mol Neurobiol. Jun 25, 2015

Peroxisome proliferator-activated receptor-gamma (PPAR-γ), a stress-induced transcription factor, protects neurons against ischemic st ...

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Dr. Chern , Yijuang
A central role of TRAX in the ATM-mediated DNA repair.
Oncogene. Jun 22, 2015

DNA repair is critical for the maintenance of genome stability. Upon genotoxic stress, dysregulated DNA repair may induce apoptosis. Transli ...

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Dr. Shyu , Bai Chuang
Targeting P2X7 receptor for the treatment of central post-stroke pain in a rodent model.
Neurobiol Dis. May 30, 2015

Stroke is a leading cause of death and disability in industrialized countries. Approximately 8-14% of stroke survivors suffer from central p ...

Years