Dr. Chern, Yijuang 's publons link picture

Dr. Chern, Yijuang

Distinguished Research Fellow
  • +886227899028 (Lab) (Room No: N333)
  • +886226523913 (Office)
  • 02-27829143 (Fax)

  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease

Education and Positions:
  • Ph.D. Univ. of Massachusetts

Highlight Detail

Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.

Dr. Chern, Yijuang
Hum. Mol. Genet., Aug 11, 2015

Huntington's disease (HD) is an autosomal dominant degenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (htt) gene. The most vulnerable brain areas to mutant HTT-evoked toxicity are the striatum and cortex. In spite of the extensive efforts that have been devoted to the characterization of HD pathogenesis, no disease-modifying therapy for HD is currently available.