配合計劃執行，協助核心設施一般行政業務與推廣

具生命科學相關科系學位

1.從事免疫調控機轉及疫苗開發之研究

2.處理交辦事項

1.具生物醫學相關科系博士

2.具免疫研究相關背景及小鼠操作經驗尤佳

具分子生物、生化、或動物實驗研究背景者

碩博士畢業五年內對細胞訊息傳遞、癌症研究有興趣者

Epitranscriptomic RNA modifications have recently emerged to be an important layer of regulation of viral host interactions, with the gene expression of multiple viruses regulated by RNA modifications, and some modifications shielding viral RNAs from immune detection. The current COVID-19 pandemic not only highlights the importance of basic virology research, but the BioNTech and Moderna RNA vaccines also showcases the practical use of RNA modifications to prevent immune destruction of RNA vaccines.

The Tsai lab is looking for highly motivated problem solvers to join our quest in exploring epitranscriptomic RNA modifications in Influenza A virus ＆ Human Immunodeficiency virus (HIV-1). For details, see: https://www.nature.com/articles/s41579-020-0382-3

Work in the lab is expected to be highly diverse and mostly molecular, including DNA molecular cloning, tissue culture of viruses, CRISPR/Cas9-mediated gene editing, protein and RNA purification work, and computational analysis of next gen sequencing (NGS) results. Prior related experiences preferred but not required.

徵求有興趣探索病毒RNA修飾的研究夥伴一同來了解RNA修飾對病毒基因表現的調控與其延伸應用。目前已知RNA修飾可調控多種病毒的基因表現，並已有少數報告顯示RNA修飾可調控細胞分辨本體與外來病毒RNA。近期COVID-19疫情不但凸顯了病毒研究的重要性，最近上市的輝瑞/BNT和Moderna的SARS-CoV-2 疫苗以人工pseudouridine修飾防止細胞攻擊疫苗中的RNA的應用例子更是RNA修飾的重要應用例子。本實驗室將針對流感病毒A (Influenza A virus, IAV) 與人體免疫缺乏病毒 (HIV-1) 兩種病毒來研究RNA修飾對病毒複製與免疫辨識的影響。詳情請參考：https://www.nature.com/articles/s41579-020-0382-3

實驗室常用技術包含基因轉殖、細胞與病毒培養技術、CRISPR/Cas9基因編輯、RNA蛋白質交互作用檢驗（如PAR-CLIP）與次世代定序(NGS)資料的電腦分析。英台雙母語的蔡老師也會樂於幫實驗室同仁練習英文寫作或演講。有足夠資料可報告之實驗室成員將被鼓勵參加如美國病毒學會或RNA學會年會等國際研討會。

Preferred candidates should be active problem solvers, either though asking collages, reading papers, or designing experiments to obtain answers. Taipei is a great city for specialty coffee lovers and outdoor activity enthusiasts. The PI is Taiwanese-American and welcomes talents of all nationalities as long as the candidate can communicate in English.

We are currently looking for one PostDoc or Graduate level research assistant (RA with a Master’s degree). RAs who wish to transition to a graduate program abroad in 2-3 years are welcome.

應徵者希望是對病毒或RNA有興趣，並樂於解決問題的人。歡迎有志在本實驗室準備2-3年後出國的研究助理。需有基本的英文溝通與閱讀能力。研究需要常保腦活，因此希望實驗室成員能夠在不過勞的生活型態下保有生產力。台北四周環山，城郊自然活動場域豐富而易達；城裡有多重精品咖啡選擇，歡迎同好加入。

We are investigating a new kind of liposome invented in our lab for the treatment of cancer. The research involves learning how to make liposomes, load different cancer drugs into the liposomes, how to characterize the liposomes, and investigate the in vitro and in vivo anticancer activity of the liposomes.

The goal of this research is to form a company. This project involves also learning how to start a business in the Biotechnology Research Park of Academia Sinica. The successful candidate should be highly motivated to carry our translation research with the goal of commercializing the product.

BS or MS degreee in Biology or Chemistry related fields

Molecular mechanisms of tumor metastasis

Experience and skills of molecular, cellular and genomic biology in cancer
 

徵求有志從事跨領域生醫/神經科學研究的新成員，與我們合作開發次世代光遺傳學科技(next-generation optogenetics)。

這是一個高度跨領域的研究主題，我們結合化學、生物工程、生物物理、以及神經科學的概念與技術，發展創新的工具及方法，用以精準調控複雜的神經傳導現象。

We develop next-generation optogenetic tools for neuroscience applications.  This is a highly cross-disciplinary research field.  We integrate concepts and techniques in chemistry, bioengineering, biophysics, and neurobiology, aiming to enable precise and remote manipulation of complex neurotransmission in the brain.

生命科學、生物工程、化學或生物物理相關科系學士/碩士(for 研究助理)或博士(for 博士後研究員)畢業，熟悉或有高度意願學習神經科學相關的細胞/生化實驗、電生理、影像分析、或動物實驗 (符合一項即可)。

若有electrophysiology、microscopy (confocal, two-photon, or other advanced approaches)、mouse breeding、neuron proteomics、gene editing (e.g., CRISPR-Cas9) 或in vivo optogenetics/chemogenetics相關經驗請在申請時提出，但不是必要條件。

Ph.D., M.S. or B.S. in life sciences, bioengineering, chemistry, or biophysics.  Experienced, or highly motivated to learn one of the following: electrophysiology, microscopy (image acquisition and analysis), or animal experiments in neuroscience.  Please indicate in your application if you have experience in electrophysiology, microscopy (confocal, two-photon, or other advanced approaches), mouse breeding, neuron proteomics, gene editing (e.g., CRISPR-Cas9) or in vivo optogenetics/chemogenetics.

1).生醫資訊系統開發

2).臨床、基因大數據整理與分析

3).精準醫療計劃應用工具 Mobile App開發

1).個性積極主動負責，能團隊合作及樂於知識交流

2).有學習的熱情，不自我設限。可因應不同工作挑戰能持續地自發學習，提升自己的專業能力

3).Java、PostgresSQL、Python、Linux

4).有醫療或基因資料整理及分析經驗佳

5).有大數據處理經驗佳

6).有iOS App 開發經驗佳

(1).利用基因轉殖鼠，分子生物學，生物化學，動物行為學及生物資訊學的方法進行研究;

(2)研究幼年型肌強直症大腦發育遲緩的分子機轉;

(3) 研究先天性心臟病對大腦發育所造成之影響。

1.生命科學相關科系學士/碩士畢業。

2.有一個學習的熱忱，(i) 想學習如何利用基因轉殖鼠進行研究; (ii) 對心臟發育及神經發育有興趣; (iii) 想學習如何利用分子生物及生物化學的方法研究疾病的分子致病機轉。

1.  基本分子生物學/生化實驗操作 (例如: cloning, Western Blotting)；

2.  定期神經細胞或細胞株培養；

3.  支援其他一般事務 (例如: 實驗室目錄更新/整理、試劑耗材補充)。

生命科學、生物工程、生物科技、化學相關科系學士 or 碩士畢業。認真、細心、有高度責任感。

熟悉分子生物學/生化實驗、細胞培養、或實驗動物相關操作 (符合一項即可)。

若有化學 or 神經科學相關經歷請在申請時提出，但不是必要條件。