研究員姓名: Dr.蔡松智(Tsai,Kevin ) 徵
應徵項目: 博士後研究 1名
博研生 1名

Epitranscriptomic RNA modifications have recently emerged to be an important layer of regulation of viral host interactions, with the gene expression of multiple viruses regulated by RNA modifications, and some modifications shielding viral RNAs from immune detection. The current COVID-19 pandemic not only highlights the importance of basic virology research, but the BioNTech and Moderna RNA vaccines also showcases the practical use of RNA modifications to prevent immune destruction of RNA vaccines.

The Tsai lab is launching mid May, and looking for highly motivated problem solvers to join our quest in exploring epitranscriptomic RNA modifications in either Influenza A virus or the tumorigenic Epstein-Barr virus. For details, see: https://www.nature.com/articles/s41579-020-0382-3

Work in the lab is expected to be highly diverse and mostly molecular, including DNA molecular cloning, tissue culture of viruses, protein and RNA purification work, and computational analysis of next gen sequencing (NGS) results. Prior related experiences preferred but not required.

We are looking for post doctoral fellows, with biomedical relevant backgrounds. Graduate students who are interested in training in the lab should apply through the Academia Sinica Taiwan International Graduate Program in Molecular Medicine (TIGP, see https://tigp.sinica.edu.tw/MM.html )

Preferred candidates should be active problem solvers, either though asking collages, reading papers, or designing experiments to obtain answers. Good candidates should maintain productivity without overworking. Taipei is a great city for specialty coffee lovers and outdoor activity enthusiasts. The PI is Taiwanese-American and welcomes talents of all nationalities as long as the candidate can communicate in English.

Please contact Kevin Tsai at kevtsai@ibms.sinica.edu.tw with your CV and cover letter to discuss opportunities.

徵求有興趣探索病毒RNA修飾的研究夥伴一同來了解RNA修飾對病毒基因表現的調控與其延伸應用。目前已知RNA修飾可調控多種病毒的基因表現,並已有少數報告顯示RNA修飾可調控細胞分辨本體與外來病毒RNA。近期COVID-19疫情不但凸顯了病毒研究的重要性,最近上市的輝瑞/BNT和Moderna的SARS-CoV-2 疫苗以人工pseudouridine修飾防止細胞攻擊疫苗中的RNA的應用例子更是RNA修飾的重要應用例子。本實驗室將針對流感病毒A (Influenza A virus, IAV) 與可造成人類白血病與鼻咽癌的Epstein-Bar virus (EBV) 兩種病毒來研究RNA修飾對病毒複製與免疫辨識的影響。





有意者請把履歷( CV )寄到kevtsai@ibms.sinica.edu.tw 並在信中簡短推銷自己。

希望加入我們修習博士班的有志之士煩請申請中研院台灣國際研究生學程 (TIGP, 請見 https://tigp.sinica.edu.tw/MM.html )

2021/06/21 ~ 2021/09/26
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研究員姓名: Dr.徐經倫(Hsu,Ching-Lung ) 徵
應徵項目: 博士後研究 1名
約聘研究助理 1名
博研生 1名



運用電生理學, 行為學, 藥理學, 化學遺傳學/光學遺傳學,小鼠虛擬實境, 病毒神經迴路追蹤, 電腦數值建模, 雙光子影像等方法, 分析空間導航, 學習記憶的細胞學與生物物理學機制.

Please see here for an introduction of the research direction in the lab.

Using patch-clamp electrophysiology, pharmacology, chemogenetics/optogenetics, mouse behavior in virtual reality, virus-assisted circuit tracing, computational modeling, new two-photon imaging method, my lab aims to understand how the complexity of single-neuron computations contributes to rapidly flexible neural code for spatial navigation, learning and memory.

An introduction of research directions in the lab: https://www.dropbox.com/s/yuzfrd95m4sa6u3/Research%20Introduction%20for%20Hsu%20Lab_Aug20.pdf?dl=0

There are several graduate programs (https://www.ibms.sinica.edu.tw/templates/default/en/graduated/graduated.html) and funding sources for postdoc fellowships. The research environments in Academia Sinica are international, vibrant and highly multidisciplinary. English is a working language in the lab. Taiwan has superior living quality, is safe and embraces diversity. Subsidized National Health Insurance and work insurance are available.


對神經科學, 研究主題的興趣與熱情, 和主動學習的熱忱是最重要的條件. 有電生理, 動物實驗或生理影像經驗, 具量化分析訓練 (例如電機, 工程, 物理), 或有電腦程式, 計算模擬相關背景的可以優先考慮, 但不是必要條件. 我的實驗室研究方法有挑戰性, 但得到成果時也會很有成就感, 適合細心, 有韌性的人. 經過訓練將可在神經細胞的電生理領域, 計算的物理基礎等方面打下扎實的根基.


Your interests in the research, motivation to learn and open-mindedness are the most important things to consider. The following backgrounds or experiences are encouraged, but not required: electrophysiology (especially patch clamp), animal or imaging experiments; quantitative skills (e.g., engineering, physics or math); programming, hardware control, computational modeling. The research in the lab is both challenging and rewarding. You may gain solid foundations for understanding electrophysiological and computational principles of neurons after the trainings.

Research assistant may be expected to assist with administrative work especially during the setup phase of the lab.

2020/11/02 ~ 2021/09/30
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