2012 Highlights

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Dr. Hwang , Ming-Jing
A Critical Assessment of Information-guided Protein-protein Docking Predictions.
Mol Cell Proteomics. Dec 13, 2012

The structures of protein complexes are increasingly predicted by protein-protein docking (PPD) using ambiguous interaction data to help gui ...

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Dr. Shih , Hsiu-Ming
The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Oncogene Dec 03, 2012

Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (R ...

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Dr. Liu , Fu-Tong
Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration.
Journal of Investigative Dermatology Dec 01, 2012

The EGFR-mediated signaling pathways are important in a variety of cellular processes, including cell migration and wound re-epithelializati ...

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Dr. Cheng , Andrew Tai Ann
Changing trends in the prevalence of common mental disorders in Taiwan: a 20-year repeated cross-sectional survey.
The Lancet Nov 12, 2012

The term common mental disorders (CMDs) is a broad diagnostic category for non-psychotic, depressive, and anxiety disorders that covers most ...

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Dr. Hsieh , Patrick Ching-Ho
Xenografted human amniotic fluid-derived stem cell as a cell source in therapeutic angiogenesis.
Int J Cardiol. Oct 06, 2012

The AFSC-ECs demonstrated endothelial cell characteristics in vitro. Four weeks later, AFSC-ECs transplantation significantly increased limb ...

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Dr. Chen , Yuan-Tsong
Pharmacogenomics of adverse drug reactions: implementing personalized medicine.
Hum Mol Genet. Aug 19, 2012

Pharmacogenomics aims to investigate the genetic basis of inter-individual differences in drug responses, such as efficacy, dose requirement ...

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Dr. Chen , Chien-Chang
The Cav3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
Cardiovasc Res. Aug 10, 2012

Restenosis is an undesirable consequence following percutaneous vascular interventions. However, the current strategy for preventing resteno ...

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Dr. Hsieh , Patrick Ching-Ho
Instructive Nanofiber Scaffolds with VEGF Create a Microenvironment for Arteriogenesis and Cardiac Repair.
Sci Transl Med. Aug 08, 2012

Angiogenic therapy is a promising approach for tissue repair and regeneration. However, recent clinical trials with protein delivery or gene ...

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Dr. Hsieh , Patrick Ching-Ho
Treatment of acute thromboembolism in mice using heparin-conjugated carbon nanocapsules.
ACS Nano. Jul 24, 2012

The unsurpassed properties in electrical conductivity, thermal conductivity, strength, and surface area-to-volume ratio allow for many poten ...

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Dr. Jou , Yuh-Shan
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy.
Clin Cancer Res. Jul 18, 2012

Histone deacetylase inhibitors (HDACi) are actively explored as new-generation epigenetic drugs but have low efficacy in cancer monotherapy. ...

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