2008 Highlights

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Dr. Chen , Yuan-Tsong
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Nature Medicine. Nov 23, 2008

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening adverse drug reactions characterized by massive ...

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Dr. Chen , Yuan-Tsong
Mutations in the SLC2A10 gene cause arterial abnormalities in mice
Cardiovascular Research. Nov 21, 2008

Aims: Glucose transporter 10 (GLUT10), encoded by the SLC2A10 gene, is a member of the class III facilitative glucose transporter family. ...

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Dr. Pan , Wen-Harn
Is Ischemic Stroke Risk Related to Folate Status or Other Nutrients Correlated With Folate Intake?
American Stroke Association Nov 06, 2008

Folate status was inversely associated with plasma homocysteine concentration, a potential risk factor of cardiovascular disease. However ...

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Dr. Lim , Carmay
Common physical basis of macromolecule-binding sites in proteins.
Nucleic Acids Research Nov 06, 2008

Protein–DNA/RNA/protein interactions play critical roles in many biological functions. Previous studies have focused on the differe ...

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Dr. Shen , Chen-Yang
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
The EMBO Journal Oct 30, 2008

The DNA damage response (DDR) has an essential function in maintaining genomic stability. Ataxia telangiectasia-mutated (ATM)-checkpoint ...

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Dr. Tarn , Woan-Yuh
The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene.
MCB. Sep 15, 2008

Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene h ...

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Dr. Yang , Pan-Chyr
Claudin-1 is a Metastasis Suppressor and Correlates with Clinical Outcome in Lung Adenocarcinoma.
Am. J. Respir. Crit. Care Med. Sep 11, 2008

Rationale: Claudin-1(CLDN1), a key component of tight junction complexes, was down-regulated in human lung adenocarcinomas. Objectives: T ...

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Dr. Pan , Wen-Harn
Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides.
Hum Mutat. Jul 22, 2008

Previously, we observed that young-onset hypertension was independently associated with elevated plasma triglyceride(s) (TG) levels to a ...

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Dr. Chen , Joanne Jeou-Yuan
CD44 Engagement Promotes Matrix-derived Survival through CD44-SRC-integrin Axis in Lipid Rafts.
Mol. Cell. Biol. Jul 21, 2008

CD44 is present in detergent-resistant cholesterol-rich microdomains, called lipid rafts, in many types of cells. However, the functional ...

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Dr. Tarn , Woan-Yuh
The DEAD-box RNA Helicase DDX3 Associates with Export mRNPs as well as TAP and Participates in Translational Control.
Mol Biol Cell. Jul 02, 2008

Monitoring Editor: Peter Walter Nuclear export of mRNA is tightly linked to transcription, nuclear mRNA processing, and subsequent matura ...

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