Dr. Chen, Joanne Jeou-Yuan 's publons link picture

Dr. Chen, Joanne Jeou-Yuan

Emeritus Research Fellow

  • Cancer Genomics
  • Molecular Oncology
  • Tumor Biology

Education and Positions:
  • Ph.D. Biochemistry, University of Minnesota

Highlight Detail

CD44 Engagement Promotes Matrix-derived Survival through CD44-SRC-integrin Axis in Lipid Rafts.

Dr. Chen, Joanne Jeou-Yuan
Mol. Cell. Biol., Jul 21, 2008

CD44 is present in detergent-resistant cholesterol-rich microdomains, called lipid rafts, in many types of cells. However, the functional significance of CD44 in lipid rafts is still unknown. We have previously demonstrated that osteopontin-mediated engagement of CD44V promotes an extracellular matrix-derived survival signal through integrin activation. By using a series of CD44 mutants and pharmacological inhibitors selectively targeted to various cellular pathways