2005 Highlights

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Dr. Yang , Pan-Chyr
MicroRNA Signature Predicts Survival and Relapse in Lung Cancer.
Cancer Cell Jan 08, 2008

We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients.Using real-time RT-PCR, we obtained

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Dr. Shih , Hsiu-Ming
SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
PNAS. Nov 22, 2005

Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation.Here, we show that CREB ...

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Dr. Tarn , Woan-Yuh
Exon Selection in a-Tropomyosin mRNA Is Regulated by the Antagonistic Action of RBM4 and PTB.
Molecular and Cellular Biology Nov 01, 2005

RNA-binding motif protein 4 (RBM4) has been implicated in the regulation of precursor mRNA splicing. Using differential display analysis, ...

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Dr. Cheng , Andrew Tai Ann
A 3-Year Panel Study of Mental Disorders Among Adolescents in Taiwan
Am J Psychiatry. Jul 01, 2005

This study investigated the prevalence and changing trends of mental disorders and the effects of gender and urbanization among adolescents ...

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Dr. Chen , Yuan-Tsong
A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.
Human Molecular Genetics. May 11, 2005

Warfarin, a commonly prescribed anticoagulant, exhibited large inter-individual and inter-ethnic differences in the dose required for its ...

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Dr. Chen , Yuan-Tsong
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
PNAS. Mar 15, 2005

Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR ...

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