Dr. Jou, Yuh-Shan

Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma

Molecular Carcinogenesis, Dec 01, 2022

      Adenosine-to-inosine (A-to-I) RNA editing is the most common posttranscriptional editing to create somatic mut ......

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Dr. Hu, Che-Ming (Jack)

In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering

Advanced Healthcare Materials, Dec 01, 2022

      The intricate biochemical functionalities of cellular membranes have inspired numerous strategies for deriving ......

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Dr. Hsieh, Patrick Ching-Ho

Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration

Circulation, Nov 24, 2022

        BACKGROUND: Cardiac regeneration after injury is limited by the low proliferative capacity of adu ......

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Dr. Fann, Cathy S.-J.

Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan

Journal of Headache and Pain, Nov 21, 2022

      Background: Cluster headache is a highly debilitating neurological disorder with considerable inter-ethni ......

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Dr. Tao, Mi-Hua

A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern

Emerging Microbes & Infections, Nov 17, 2022

      Numerous vaccines have been developed to address the current COVID-19 pandemic, but safety, cross-neutralizing ......

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Dr. Chen, Shih-Yu

Spatial multi-omics analyses of the tumor immune microenvironment

Journal of Biomedical Science, Nov 14, 2022

In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcript ......

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Dr. Fann, Cathy S.-J.

Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes

Communications Biology, Nov 03, 2022

      To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS o ......

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Dr. Li, Ling-Hui

Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas

Journal of Biomedical Science, Oct 27, 2022

      Methods: Microbiota composition was determined through 16S rRNA V3-V4 amplicon sequencing of autologous a ......

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Dr. Hsieh, Patrick Ching-Ho

Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice

Theranostics, Oct 17, 2022

        Background: The gut microbiota plays a vital role in maintaining tissue homeostasis and regulat ......

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Dr. Hsieh, Patrick Ching-Ho

Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine

Theranostics, Oct 17, 2022

        Rationale: Gut microbiota plays a crucial role in cancer development and treatment. Studies sho ......

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