Dr. Shieh, Sheau-Yann
JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Cell Death & Disease, Jul 18, 2022
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the s ......
Dr. Lin, Jung-Hsin
A Curvilinear-Path Umbrella Sampling Approach to Characterizing the Interactions Between Rapamycin and Three FKBP12 Variants
Frontiers in Molecular Biosciences, Jul 08, 2022
Rapamycin is an immunosuppressant macrolide that exhibits anti-proliferative properties through inhibiting the ......
Dr. Tao, Mi-Hua
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants
Journal of Biomedical Science, Jul 07, 2022
Background: With the continuous emergence of new SARS-CoV-2 variants that feature increased transmissio ......
Dr. Pan, Wen-Harn
Healthy Taiwanese Eating Approach (TEA) toward Total Wellbeing and Healthy Longevity
Nutrients, Jul 05, 2022
A healthy dietary pattern review for Asian countries is scarce, which is crucial for guiding healthy eating. W ......
Dr. Chen, Huan-Yuan
Galectin-3 facilitates cell-to-cell HIV-1 transmission by altering the composition of membrane lipid rafts in CD4 T cells
Glycobiology, Jul 05, 2022
Galectin-3 (GAL3) is a β-galactoside-binding lectin expressed in CD4 T cells infected with human immunode ......
Dr. Chen, Chien-Chang
Cav3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis
Journal of thrombosis and haemostasis, Jul 01, 2022
Cav3.2 is a T-type calcium channel that causes low-threshold exocytosis. T-type calcium channe ......
Dr. Chen, Chien-Chang
Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy
Journal of Molecular and Cellular Cardiology Plus, Jun 27, 2022
Cardiac pressure overload induces cardiac hypertrophy and eventually leads to heart ......
Dr. Hu, Yu-Feng
Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes
Circulation Research, Jun 24, 2022
Methods: Tbx18 (T-box transcription factor 18)-induced PCs and fibroblasts were used for cocultures and e ......
Dr. Shih, Chiaho
Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
Journal of Biomedical Science, Jun 21, 2022
Background: Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative tr ......
Dr. Shih, Hsiu-Ming
Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth
Cellular and Molecular Life Sciences, Jun 19, 2022
Upregulation of death-domain-associated protein (Daxx) is strongly associated with diverse cancer types. Among ......