Dr. Shieh, Sheau-Yann

JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability

Cell Death & Disease, Jul 18, 2022

      Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the s ......

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Dr. Lin, Jung-Hsin

A Curvilinear-Path Umbrella Sampling Approach to Characterizing the Interactions Between Rapamycin and Three FKBP12 Variants

Frontiers in Molecular Biosciences, Jul 08, 2022

      Rapamycin is an immunosuppressant macrolide that exhibits anti-proliferative properties through inhibiting the ......

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Dr. Tao, Mi-Hua

A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

Journal of Biomedical Science, Jul 07, 2022

      Background: With the continuous emergence of new SARS-CoV-2 variants that feature increased transmissio ......

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Dr. Pan, Wen-Harn

Healthy Taiwanese Eating Approach (TEA) toward Total Wellbeing and Healthy Longevity

Nutrients, Jul 05, 2022

      A healthy dietary pattern review for Asian countries is scarce, which is crucial for guiding healthy eating. W ......

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Dr. Chen, Huan-Yuan

Galectin-3 facilitates cell-to-cell HIV-1 transmission by altering the composition of membrane lipid rafts in CD4 T cells

Glycobiology, Jul 05, 2022

      Galectin-3 (GAL3) is a β-galactoside-binding lectin expressed in CD4 T cells infected with human immunode ......

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Dr. Chen, Chien-Chang

Cav3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis

Journal of thrombosis and haemostasis, Jul 01, 2022

      Background Cav3.2 is a T-type calcium channel that causes low-threshold exocytosis. T-type calcium channe ......

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Dr. Chen, Chien-Chang

Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy

Journal of Molecular and Cellular Cardiology Plus, Jun 27, 2022

      Background Cardiac pressure overload induces cardiac hypertrophy and eventually leads to heart ......

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Dr. Hu, Yu-Feng

Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes

Circulation Research, Jun 24, 2022

      Methods: Tbx18 (T-box transcription factor 18)-induced PCs and fibroblasts were used for cocultures and e ......

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Dr. Shih, Chiaho

Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

Journal of Biomedical Science, Jun 21, 2022

      Background: Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative tr ......

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Dr. Shih, Hsiu-Ming

Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth

Cellular and Molecular Life Sciences, Jun 19, 2022

      Upregulation of death-domain-associated protein (Daxx) is strongly associated with diverse cancer types. Among ......

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