Dr. Chen, Chih-Cheng Targeting ASIC3 for pain, anxiety, and insulin resistance.
Pharmacol Ther., Dec 30, 2011Acid-sensing ion channel 3 (ASIC3) is a sensitive pH sensor predominantly expressed in nociceptors and responds to mild extracellular acidif ......
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Dr. Huang, Yi-Shuian CPEB2–eEF2 interaction impedes HIF-1α RNA translation
EMBO J, Dec 09, 2011Translation of mRNA into protein proceeds in three phases: initiation, elongation, and termination. Regulated translation allows the prompt ......
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Dr. Lim, Carmay GeoPCA: a new tool for multivariate analysis of dihedral angles based on principal component geodesics.
Nucl. Acids Res, Dec 01, 2011The GeoPCA package is the first tool developed for multivariate analysis of dihedral angles based on principal component geodesics. Principa ......
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Dr. Jou, Yuh-Shan IGDB.NSCLC: integrated genomic database of non-small cell lung cancer.
Nucl. Acids Res, Dec 01, 2011Lung cancer is the most common cause of cancer-related mortality with more than 1.4 million deaths per year worldwide. To search for signifi ......
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Dr. Chen, Chih-Cheng An antinociceptive role for substance P in acid-induced chronic muscle pain.
PNAS, Nov 14, 2011Release of substance P (SP) from nociceptive nerve fibers and activation of its receptor neurokinin 1 (NK1) are important effectors in the t ......
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Dr. Shieh, Sheau-Yann Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis.
Oncogene, Oct 24, 2011The B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and a downstream target of p53. BTG3 also binds ......
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Dr. Tang, Tang K. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.
EMBO, Oct 21, 2011Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary m ......
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Dr. Chern, Yijuang Type VI adenylyl cyclase (AC6) regulates neurite extension by binding to Snapin and Snap25.
Mol. Cell. Biol., Oct 10, 20113' -5' -Cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates neurite outgrowth. We demonstrate her ......
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Dr. Jou, Yuh-Shan Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma.
Oncogene, Sep 26, 2011Common genetic alteration in cancer genomes is implicated for embracing an aberrant cancer gene participated in tumor progression. In this s ......
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Dr. Chen, Yuan-Tsong Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
J Allergy Clin Immunol., Sep 14, 2011Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), are life-threatening drug hypersensitivities with ......
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