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Dr. Chern, Yijuang

Director
Distinguished Research Fellow
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Specialty:
  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease

Education and Positions:
  • Ph.D. Univ. of Massachusetts


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Type VI adenylyl cyclase (AC6) regulates neurite extension by binding to Snapin and Snap25.

Dr. Chern, Yijuang
Mol. Cell. Biol., Oct 10, 2011

3' -5' -Cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates neurite outgrowth. We demonstrate herein that type VI adenylyl cyclase (AC6), an enzyme which catalyzes cAMP synthesis, regulates neurite outgrowth by direct interaction with a binding protein (Snapin) of Snap25 at the N-terminus of AC6 (AC6-N). We first showed that AC6 expression increased during