Dr. Chang, Ya-Jen Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis
Theranostics, Jan 01, 2021Rationale The major cause of heart failure is myocardium death consequent to detrimental cardiac remodeling and fibrosis follow ......
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Dr. Shen, Chen-Yang Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People
Molecular Biology and Evolution, Dec 18, 2020Abstract The Taiwanese people are composed of diverse indigenous populations and the Taiwanese Han. About 95% of the Taiwanese identify ......
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Dr. Shieh, Sheau-Yann Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation
Cell Death & Disease, Dec 11, 2020Abstract B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53 ......
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Dr. Yang, Ruey-Bing (Ray)SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling
American Journal of Human Genetics, Dec 11, 2020Summary Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) is a member of a small family of multifunctional cell surface-ancho ......
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Dr. Yang, Pan-Chyr Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
EMBO Molecular Medicine, Nov 30, 2020Abstract To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a hum ......
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Dr. Lee, Te-Chang SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells
Cancers, Nov 26, 2020Simple Summary IFIT2 depletion is associated with increased epithelial-mesenchymal transition and metastasis. The main aim of our s ......
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Dr. Yang, Pan-Chyr Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
Journal for ImmunoTherapy of Cancer, Nov 26, 2020Abstract Background: The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) ha ......
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Dr. Chau, Lee-Young Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology, Nov 05, 2020Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......
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Dr. Kwok, Pui-Yan Towards a reference genome that captures global genetic diversity
Nature Communications, Oct 30, 2020Abstract The current human reference genome is predominantly derived from a single individual and it does not adequately reflect human ......
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Dr. Huang, Yi-Shuian CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling
Cell Reports, Oct 20, 2020Summary Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. ......
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