2020 Highlights

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Dr. Chang , Ya-Jen
Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis
Theranostics Jan 01, 2021

  Rationale The major cause of heart failure is myocardium death consequent to detrimental cardiac remodeling and fibrosis follow ...

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Dr. Shen , Chen-Yang
Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People
Molecular Biology and Evolution Dec 18, 2020

Abstract The Taiwanese people are composed of diverse indigenous populations and the Taiwanese Han. About 95% of the Taiwanese identify ...

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Dr. Shieh , Sheau-Yann
Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation
Cell Death & Disease Dec 11, 2020

Abstract B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53 ...

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Dr. Yang , Ruey-Bing (Ray)
SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling
American Journal of Human Genetics Dec 11, 2020

Summary Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) is a member of a small family of multifunctional cell surface-ancho ...

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Dr. Yang , Pan-Chyr
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
EMBO Molecular Medicine Nov 30, 2020

Abstract To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a hum ...

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Dr. Lee , Te-Chang
SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells
Cancers Nov 26, 2020

Simple Summary IFIT2 depletion is associated with increased epithelial-mesenchymal transition and metastasis. The main aim of our s ...

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Dr. Yang , Pan-Chyr
Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
Journal for ImmunoTherapy of Cancer Nov 26, 2020

Abstract Background:  The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) ha ...

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Dr. Chau , Lee-Young
Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology Nov 05, 2020

Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ...

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Dr. Kwok , Pui-Yan
Towards a reference genome that captures global genetic diversity
Nature Communications Oct 30, 2020

Abstract The current human reference genome is predominantly derived from a single individual and it does not adequately reflect human ...

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Dr. Huang , Yi-Shuian
CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling
Cell Reports Oct 20, 2020

Summary Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. ...

Years