2018 Highlights

...
Dr. Chern , Yijuang
Degeneration of ipRGCs in mouse models of Huntington's Disease disrupts non-image forming behaviors prior to motor impairment
Journal of Neuroscience Dec 26, 2018

Intrinsically photosensitive retinal ganglion cells (ipRGCs), which express the photopigment melanopsin, are photosensitive neurons in the r ...

...
Dr. Hsieh , Patrick Ching-Ho
Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme
ACS Nano Dec 11, 2018

The blood–brain barrier (BBB) selectively controls the passage of endogenous and exogenous molecules between systemic circulation and ...

...
Dr. Tarn , Woan-Yuh
Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV
Molecular Therapy-Nucleic Acids Dec 10, 2018

The molecular chaperon MRJ (DNAJB6) exhibits two splice isoforms that have different roles in human viral infection, but the regulatory mech ...

...
Dr. Lin , Yi-Ling
Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis
Emerging Microbes & Infections Nov 21, 2018

The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (J ...

...
Dr. Lim , Carmay
How Pb2+ Binds and Modulates Properties of Ca2+-Signaling Proteins
Inorganic Chemistry Nov 09, 2018

Abiogenic lead (Pb2+), present in the environment in elevated levels due to human activities, has detrimental effects on human health. Metal ...

...
Dr. Yang , Ruey-Bing (Ray)
SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury
Biochimica et biophysica acta: molecular basis of disease Nov 07, 2018

We previously reported that the membrane-bound SCUBE1 (signal peptide-CUB-epithelial growth factor domain-containing protein 1) forms a comp ...

...
Dr. Shui , Jr-Wen
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases
Frontiers in Immunology Nov 05, 2018

In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the ...

...
Dr. Lee , Te-Chang
Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer
Cancers Oct 22, 2018

Aberrant DNA methylation is a potential mechanism underlying the development of colorectal cancer (CRC). Thus, identification of prognostic ...

...
Dr. Chau , Lee-Young
Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
Oncogene Oct 22, 2018

Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ...

...
Dr. Hu , Che-Ming (Jack)
725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria
Acta Biomaterialia Oct 11, 2018

Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ...

Years