陳儀莊 博士Degeneration of ipRGCs in mouse models of Huntington's Disease disrupts non-image forming behaviors prior to motor impairment
Journal of Neuroscience, Dec 26, 2018
Intrinsically photosensitive retinal ganglion cells (ipRGCs), which express the photopigment melanopsin, are photosensitive neurons in the r ......
謝清河 博士Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme
ACS Nano, Dec 11, 2018
The blood–brain barrier (BBB) selectively controls the passage of endogenous and exogenous molecules between systemic circulation and ......
譚婉玉 博士Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV
Molecular Therapy-Nucleic Acids, Dec 10, 2018
The molecular chaperon MRJ (DNAJB6) exhibits two splice isoforms that have different roles in human viral infection, but the regulatory mech ......
林宜玲 博士Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis
Emerging Microbes & Infections, Nov 21, 2018
The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (J ......
林小喬 博士How Pb2+ Binds and Modulates Properties of Ca2+-Signaling Proteins
Inorganic Chemistry, Nov 09, 2018
Abiogenic lead (Pb2+), present in the environment in elevated levels due to human activities, has detrimental effects on human health. Metal ......
楊瑞彬 博士SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury
Biochimica et biophysica acta: molecular basis of disease, Nov 07, 2018
We previously reported that the membrane-bound SCUBE1 (signal peptide-CUB-epithelial growth factor domain-containing protein 1) forms a comp ......
徐志文 博士ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases
Frontiers in Immunology, Nov 05, 2018
In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the ......
李德章 博士Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer
Cancers, Oct 22, 2018
Aberrant DNA methylation is a potential mechanism underlying the development of colorectal cancer (CRC). Thus, identification of prognostic ......
趙麗洋 博士Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
Oncogene, Oct 22, 2018
Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ......
胡哲銘 博士725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria
Acta Biomaterialia, Oct 11, 2018
Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ......
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