鄭泰安 博士Variant GADL1 and Response to Lithium Therapy in Bipolar I Disorder.
N Engl J Med., Dec 25, 2013
Background Lithium has been a first-line choice for maintenance treatment of bipolar disorders to prevent relapse of mania and depression, b ......
陳金榜 博士Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae.
Nucl. Acids Res., Dec 25, 2013
Klebsiella pneumoniae PmrA is a polymyxin-resistance-associated response regulator. The C-terminal effector/DNA-binding domain of PmrA (PmrA ......
張程 博士Negative cerebral blood volume fMRI response coupled with Ca2+-dependent brain activity in a dopaminergic road map of nociception.
Neuroimage, Dec 22, 2013
Decreased cerebral blood volume/flow (CBV/CBF) contributes to negative blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signals. Bu ......
林天南 博士15-Deoxy-∆12,14-PGJ 2, by Activating Peroxisome Proliferator-Activated Receptor-Gamma, Suppresses p22phox Transcription to Protect Brain Endothelial Cells Against Hypoxia-Induced Apoptosis.
Mol Neurobiol., Dec 19, 2013
15-Deoxy-∆12,14-PGJ2 (15d-PGJ2) and thiazolidinedione attenuate reactive oxygen species (ROS) production via a peroxisome proliferator-activ ......
施嘉和 博士Nucleic Acid Chaperone Activity Associated with the ARD Domain of Human Hepatitis B Virus Core Protein.
J Virol., Dec 18, 2013
Hepatitis B virus (HBV) DNA replication occurs within the HBV icosahedral core particles. HBV core protein (HBc) contains an arginine-rich d ......
林小喬 博士Identifying RNA-binding residues based on evolutionary conserved structural and energetic features.
Nucl. Acids Res., Dec 16, 2013
Increasing numbers of protein structures are solved each year, but many of these structures belong to proteins whose sequences are homologou ......
唐堂 博士(invited News and Views article) Centriole biogenesis in multiciliated cells.
Nat Cell Biol., Dec 02, 2013
Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost sim ......
陳儀莊 博士The A2A adenosine receptor is a dual-coding gene: a novel mechanism of gene usage and signal transduction.
JBC, Nov 29, 2013
The A2A adenosine receptor (A2AR) is a G protein-coupled receptor and a major target of caffeine. The A2AR gene encodes alternative transcri ......
楊瑞彬 博士Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition
J Cell Sci., Nov 08, 2013
SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2) belongs to a secreted and membrane-associated multi-domain SCUBE protein family. ......
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