2013 成果

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鄭泰安 博士
Variant GADL1 and Response to Lithium Therapy in Bipolar I Disorder.
N Engl J Med. Dec 25, 2013

Background Lithium has been a first-line choice for maintenance treatment of bipolar disorders to prevent relapse of mania and depression, b ...

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陳金榜 博士
Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae.
Nucl. Acids Res. Dec 25, 2013

Klebsiella pneumoniae PmrA is a polymyxin-resistance-associated response regulator. The C-terminal effector/DNA-binding domain of PmrA (PmrA ...

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張程 博士
Negative cerebral blood volume fMRI response coupled with Ca2+-dependent brain activity in a dopaminergic road map of nociception.
Neuroimage Dec 22, 2013

Decreased cerebral blood volume/flow (CBV/CBF) contributes to negative blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signals. Bu ...

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林天南 博士
15-Deoxy-∆12,14-PGJ 2, by Activating Peroxisome Proliferator-Activated Receptor-Gamma, Suppresses p22phox Transcription to Protect Brain Endothelial Cells Against Hypoxia-Induced Apoptosis.
Mol Neurobiol. Dec 19, 2013

15-Deoxy-∆12,14-PGJ2 (15d-PGJ2) and thiazolidinedione attenuate reactive oxygen species (ROS) production via a peroxisome proliferator-activ ...

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施嘉和 博士
Nucleic Acid Chaperone Activity Associated with the ARD Domain of Human Hepatitis B Virus Core Protein.
J Virol. Dec 18, 2013

Hepatitis B virus (HBV) DNA replication occurs within the HBV icosahedral core particles. HBV core protein (HBc) contains an arginine-rich d ...

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林小喬 博士
Identifying RNA-binding residues based on evolutionary conserved structural and energetic features.
Nucl. Acids Res. Dec 16, 2013

Increasing numbers of protein structures are solved each year, but many of these structures belong to proteins whose sequences are homologou ...

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唐堂 博士
(invited News and Views article) Centriole biogenesis in multiciliated cells.
Nat Cell Biol. Dec 02, 2013

Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost sim ...

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陳儀莊 博士
The A2A adenosine receptor is a dual-coding gene: a novel mechanism of gene usage and signal transduction.
JBC Nov 29, 2013

The A2A adenosine receptor (A2AR) is a G protein-coupled receptor and a major target of caffeine. The A2AR gene encodes alternative transcri ...

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楊瑞彬 博士
Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition
J Cell Sci. Nov 08, 2013

SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2) belongs to a secreted and membrane-associated multi-domain SCUBE protein family. ...

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黃怡萱 博士
Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors.
J Neurosci. Oct 23, 2013

Long-term memory requires activity-dependent synthesis of plasticity-related proteins (PRPs) to strengthen synaptic efficacy and consequentl ...

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