2024 成果

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譚婉玉 博士
DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1
Cell Reports Mar 13, 2024

Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-canc ...

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黃聖言 博士
A Facile NMR Method for Pre-MRI Evaluation of Trigger-Responsive T1 Contrast Enhancement
Small Methods Mar 08, 2024

There is a growing interest in developing paramagnetic nanoparticles as responsive magnetic resonance imaging (MRI) contrast agents, which f ...

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羅傅倫 博士
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs
Journal of Controlled Release Feb 28, 2024

Engineering human enzymes for therapeutic applications is attractive but introducing new amino acids may adversely affect enzyme stability a ...

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鈴木淳 博士
In vivo CRISPR screening directly targeting testicular cells
Cell Genomics Feb 27, 2024

CRISPR-Cas9 short guide RNA (sgRNA) library screening is a powerful approach to understand the molecular mechanisms of biological phenomena. ...

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李育儒 博士
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
Molecular Cell Feb 19, 2024

UFMylation is an emerging ubiquitin-like post-translational modification that regulates various biological processes. Dysregulation of the U ...

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陳世淯 博士
Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness
Frontiers in Immunology Feb 15, 2024

Immunosuppression increases the risk of nosocomial infection in patients with chronic critical illness. This exploratory study aimed to dete ...

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張雅貞 博士
Staphylococcus aureus exacerbates dermal IL-33-ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin
JCI Insight Feb 06, 2024

Atopic dermatitis (AD) is a persistent skin disease typified by symptoms of dry skin and recurrent eczema. AD patients are at heightened ris ...

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沈志陽 博士
miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells
Cancers (Basel) Feb 03, 2024

Hypoxia-inducible factor 1α (HIF-1α) plays a pivotal role in the survival, metastasis, and response to treatment of solid tumors ...

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黃怡萱 博士
Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural Primary Cultures and Stem Cells
ACS Nano Jan 29, 2024

Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology. Exis ...

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李家偉 博士
Post-translational Modification of PD-1: Potential Pathways for Cancer Immunotherapy
Cancer Research Jan 17, 2024

Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity following engagement with its ligand PD-L1. ...

Years