2024 成果

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唐堂 博士
Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model
eLife Oct 10, 2024

Polarization is crucial for the proper functioning of epithelial cells. Early polarization features include the trafficking and enrichment o ...

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黃怡萱 博士
CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesity
Molecular Metabolism Sep 20, 2024

Objective: Brown adipose tissue (BAT) plays an important role in mammalian thermogenesis through the expression of uncoupling protein 1 ...

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陳儀莊 博士
Metabolic dysregulation in Huntington's disease: Neuronal and glial perspectives
Neurobiology of Disease Sep 19, 2024

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutant huntingtin protein with an abnormal CAG ...

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林小喬 博士
PPI-hotspotID for detecting protein-protein interaction hot spots from the free protein structure
eLife Sep 16, 2024

Experimental detection of residues critical for protein-protein interactions (PPI) is a time-consuming, costly, and labor-intensive process. ...

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鈴木淳 博士
Phospholipid scrambling induced by an ion channel/metabolite transporter complex
Nature Communications Aug 31, 2024

Cells establish the asymmetrical distribution of phospholipids and alter their distribution by phospholipid scrambling (PLS) to adapt to env ...

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陳建璋 博士
Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain
PNAS Nexus Aug 30, 2024

Hyperalgesic priming, a form of pain plasticity initiated by initial injury, leads to heightened sensitivity to subsequent noxious stimuli, ...

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羅傅倫 博士
Liposomes with Low Levels of Grafted Poly(ethylene glycol) Remain Susceptible to Destabilization by Anti-Poly(ethylene glycol) Antibodies
ACS Nano Aug 09, 2024

Binding of anti-PEG antibodies to poly(ethylene glycol) (PEG) on the surface of PEGylated liposomal doxorubicin (PLD) in vitro and ...

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李國昇 博士
Transformation of neural coding for vibrotactile stimuli along the ascending somatosensory pathway
Neuron Aug 06, 2024

In mammals, action potentials fired by rapidly adapting mechanosensitive afferents are known to reliably time lock to the cycles of a vibrat ...

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黃怡萱 博士
CPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
Journal of Biomedical Science Jul 11, 2024

Background: Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and ...

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胡哲銘 博士
High-Affinity Superantigen-Based Trifunctional Immune Cell Engager Synergizes NK and T Cell Activation for Tumor Suppression
Advanced Science Jun 27, 2024

The development of immune cell engagers (ICEs) can be limited by logistical and functional restrictions associated with fusion protein desig ...

Years