陳儀莊博士

A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis

Movement Disorders, Dec 23, 2021

Background: Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansi ......

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楊鎧鍵博士

Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling

Gut , Dec 21, 2021

Background and objectives: Liver fibrosis (LF) occurs following chronic liver injuries. Cur ......

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李育儒博士

WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models

Journal of Clinical Investigation, Dec 15, 2021

Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysf ......

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羅傅倫博士

Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice

Biomedicine & Pharmacotherapy, Dec 06, 2021

Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ......

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李永凌博士

Investigating Obesity-related Risk Factors for Childhood Asthma

Pediatric Allergy and Immunology, Dec 02, 2021

Background: We tested the hypothesis that multiple obesity-related risk factors (obesity, physical activity, cardio ......

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譚婉玉博士

Antisense Oligonucleotide-Based Therapy of Viral Infections

Pharmaceutics, Nov 26, 2021

Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine develo ......

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李家偉博士

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

EBioMedicine, Nov 25, 2021

Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ......

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鄭敬楓博士

The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning

Biomedicine & Pharmacotherapy, Nov 25, 2021

In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ......

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胡瑜峰博士

Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats

Nature Biomedical Engineering , Nov 22, 2021

Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ......

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