黃聖言 博士

A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors

Biomedicines, Oct 13, 2021

We developed a new probe, Gd-DO3A-Am-PBA, for imaging tumors. Our results showed active targeting of Gd-DO3A-Am-PBA to sialic acid (SA) moie ......

詳情

陳儀莊 博士

Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

Journal of Biomedical Science, Oct 11, 2021

    In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively ......

詳情

陳儀莊 博士

A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Neurobiology of Disease, Oct 08, 2021

    Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons ......

詳情

陳志成 博士

ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

eLife, Sep 27, 2021

    CNS neurons have no sensory function, protected by the skull. For this reason, brain neuromodulation by ultrasound were ......

詳情

譚婉玉 博士

DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

iScience, Sep 24, 2021

    Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in ora ......

詳情

羅傅倫 博士

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

ACS Nano, Sep 02, 2021

    Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ......

詳情

李德章 博士

Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links

Journal of Medicinal Chemistry, Aug 30, 2021

    Designing hybrid molecules with dual functions is one approach to improve the therapeutic efficacy of combination treatm ......

詳情

沈志陽 博士

Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study

American Journal of Cancer Research, Aug 30, 2021

The causal relationship between body mass index (BMI) and type 2 diabetes (T2D) and breast cancer prognosis is still ambiguous. The aim of t ......

詳情

譚婉玉 博士

p53 Activation in Genetic Disorders: Different Routes to the Same Destination

International journal of molecular sciences, Aug 27, 2021

    The tumor suppressor p53 is critical for preventing neoplastic transformation and tumor progression. Inappropriate activ ......

詳情

黃怡萱 博士

Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke

Molecular Neurobiology, Aug 19, 2021

    Stroke is the leading cause of permanent disability and death in the world. The therapy for acute stroke is still limite ......

詳情

記錄 1 到 10 共 47 筆資料