2010 Highlights

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Dr. Wu , Cheng-Wen
Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal Transdifferentiation.
Cancer Res. Dec 15, 2010

Epithelial–mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness property of ...

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Dr. Liao , Fang
Interferon-stimulated gene ISG12b2 is localized to the inner mitochondrial membrane and mediates virus-induced cell death.
Cell Death Differ. Dec 10, 2010

Interferons (IFNs) are crucial for host defence against viruses. Many IFN-stimulated genes (ISGs) induced by viral infection exert antiviral ...

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Dr. Chen , Steve S.-L.
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro.
J Clin Invest. Dec 06, 2010

Hepatitis C virus (HCV) is a major cause of chronic liver disease, with more than 170 million infected individuals worldwide . In 50%– ...

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Dr. Yan , Yu-Ting
Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV.
Hum Mol Genet Nov 30, 2010

Glycogen storage disease type IV (GSD-IV) is an autosomal recessive disease caused by a deficiency in glycogen-branching enzyme (GBE1) activ ...

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Dr. Lin , Wen-chang
dbDNV: a resource of duplicated gene nucleotide variants in human genome.
Nucleic Acids Res Nov 21, 2010

Gene duplications are scattered widely throughout the human genome. A single-base difference located in nearly identical duplicated segments ...

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Dr. Lee , Eminy H.Y.
Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning.
EMBO J Nov 19, 2010

By using differential display PCR, we have previously identified 98 cDNA fragments from rat dorsal hippocampus, which are expressed differen ...

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Dr. Jou , Yuh-Shan
IGRhCellID: integrated genomic resources of human cell lines for identification.
Nucleic Acids Research Nov 04, 2010

Cell line identification is emerging as an essential method for every cell line user in research community to avoid using misidentified cell ...

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Dr. Lim , Carmay
Factors Controlling the Mechanism of NAD(+) Non-Redox Reactions.
J Am Chem Soc. Nov 03, 2010

β-Nicotinamide adenine dinucleotide (NAD(+)) is an indispensable coenzyme or substrate for enzymes involved in catalyzing redox and non ...

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Dr. Wu , Cheng-Wen
EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF.
Cancer Res. Nov 01, 2010

MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs co ...

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Dr. Shih , Chiaho
Nuclear Export and Import of Human Hepatitis B Virus Capsid Protein and Particles.
PLoS Pathogens Oct 28, 2010

It remains unclear what determines the subcellular localization of hepatitis B virus (HBV) core protein (HBc) and particles. To address this ...

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