2007 Highlights

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Dr. Lim , Carmay
All-Electron Calculations of the Nucleation Structures in Metal-Induced Zinc-Finger Folding: Role of the Peptide Backbone.
J. Am. Chem. Soc. Sep 21, 2007

Although the folding of individual protein domains has been extensively studied both experimentally and theoretically

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Dr. Yen , Jeffrey J.Y.
CBAP interacts with the un-liganded common b-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.
Oncogene. Sep 10, 2007

The cytoplasmic domain of the common -chain (c) of the granulocyte–macrophage-colony-stimulating factor (GM-CSF)/interleukin-3 (IL- ...

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Dr. Chang , Chen
Multiparametric MRI evaluation of kainic acid-induced neuronal activation in rat hippocampus.
Brain Advance Access. Sep 04, 2007

We investigated the pathogenic mechanisms of hippocampal structural changes and neuronal activation in a kainic acid (KA)-treated rat mod ...

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Dr. Lin , Wen-chang
Vir-Mir db: prediction of viral microRNA candidate hairpins.
Nucleic Acids Research. Aug 15, 2007

MicroRNAs have been found in various organisms and play essential roles in gene expression regulation of many critical cellular processes ...

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Dr. Yang , Pan-Chyr
Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer.
Clinical Cancer Research. Aug 15, 2007

Neuropilin 1 (NRP1) is a mediator of lung branching and angiogenesis in embryonic development and angiogenesis in cancer. The role of NRP ...

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Dr. Chen , Yuan-Tsong
HLA-B *1502-bound peptides: Implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome.
J Allergy Clin Immunol. Aug 11, 2007

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) can involve MHC-restricted presentation of a drug or its metabolites ...

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Dr. Shieh , Sheau-Yann
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1
The EMBO Journal Aug 09, 2007

Proper regulation of cell cycle progression is pivotal for maintaining genome stability. In a search for DNA damage-inducible, CHK1-modul ...

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Dr. Lin , Wen-chang
Wobble splicing reveals the role of the BPS-to-NAGNAG region in 3' tandem splice site selection.
Mol. Cell. Biol. Jun 11, 2007

Alternative splicing involving the 3' tandem splice site NAGNAG may play a role in structure-function diversity of proteins. However, ...

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Dr. Lee , Eminy H.Y.
Protein Kinase CK2 Impairs Spatial Memory Formation through Differential Cross Talk with PI-3 Kinase Signaling: Activation of Akt and Inactivation of SGK1.
The Journal of Neuroscience Jun 06, 2007

Casein kinase II (CK2) is a multifunctional serine/threonine protein kinase that is associated with the development of neuritogenesis and ...

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Dr. Yao , Wen-Hsuang
PrimerZ: streamlined primer design for promoters, exons and human SNPs
Nucleic Acids Research. May 31, 2007

PrimerZ is a web application dedicated primarily to primer design for genes and human SNPs. PrimerZ accepts genes by gene name or Ensembl ...

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