2014 Highlights

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Dr. Yang , Ruey-Bing (Ray)
Receptor guanylyl cyclase‐G is a novel thermosensory protein activated by cool temperatures.
EMBO J. Dec 01, 2014

Transmembrane guanylyl cyclases (GCs), with activity regulated by peptide ligands and/or calcium‐binding proteins, are essential for various ...

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Dr. Tarn , Woan-Yuh
Alanine repeats influence protein localization in splicing speckles and paraspeckles.
Nucleic Acids Res. Nov 20, 2014

Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confe ...

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Dr. Hsieh , Patrick Ching-Ho
Circulating Cells Contribute to Cardiomyocyte Regeneration After Injury.
Circ Res. Nov 14, 2014

Rationale: The contribution of bone marrow-borne hematopoietic cells to the ischemic myocardium has been documented. However, a pivotal stud ...

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Dr. Lim , Carmay
Ion Selectivity Strategies of Sodium Channel Selectivity Filters.
Acc Chem Res. Oct 24, 2014

Conspectus Sodium ion channels selectively transport Na+ cations across the cell membrane. These integral parts of the cell machinery are im ...

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Dr. Tarn , Woan-Yuh
TRAP150 activates splicing in composite terminal exons.
Nucl. Acids Res. Oct 17, 2014

The spliceosomal factor TRAP150 is essential for pre-mRNA splicing in vivo and, when overexpressed, it enhances splicing efficiency. In this ...

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Dr. Chern , Yijuang
Activation of AMP- activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
Hum Mol Genet. Sep 25, 2014

TAR DNA-binding protein-43 (TDP-43) is a nuclear RNA-binding protein involved in many cellular pathways. TDP-43-positive inclusions are a ha ...

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Dr. Tai , Jung-Hsiang
Signal transduction triggered by iron to induce the nuclear importation of a Myb3 transcription factor in the parasitic protozoan, Trichomonas vaginalis.
J Biol Chem. Sep 02, 2014

Iron was previously shown to induce rapid nuclear translocation of a Myb3 transcription factor in the protozoan parasite, Trichomonas vagina ...

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Dr. Shih , Chiaho
Immunodeficient Mouse Models with Different Disease Profiles by in vivo Infection with the Same Clinical Isolate of Enterovirus 71.
J Virol. Aug 20, 2014

Like poliovirus, severe infection with enterovirus 71 (EV71) can cause neuropathology. Unlike poliovirus, EV71 is often associated with hand ...

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Dr. Tarn , Woan-Yuh
DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway.
Oncogene. Jul 21, 2014

The DEAD-box RNA helicase DDX3 is a versatile protein involved in multiple steps of gene expression and various cellular signaling pathways. ...

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Dr. Lee , Eminy H.Y.
CREB SUMOylation by the E3 Ligase PIAS1 Enhances Spatial Memory.
J. Neurosci. Jul 16, 2014

cAMP-responsive element binding protein (CREB) phosphorylation and signaling plays an important role in long-term memory formation, but othe ...

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