Dr. Lee, Eminy H.Y. 's publons link picture

Dr. Lee, Eminy H.Y.

Distinguished Research Fellow
  • 02-27899125 (Lab) (Room No: 308)
  • 02-27829224 (Fax)

  • Pathogenesis of and Neuroprotection against Alzheimer's Disease
  • Molecular Mechanism of Mammalian Long-Term Memory Formation

Education and Positions:
  • Ph.D. Univ. of California, San Diego

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CREB SUMOylation by the E3 Ligase PIAS1 Enhances Spatial Memory.

Dr. Lee, Eminy H.Y.
J. Neurosci., Jul 16, 2014

cAMP-responsive element binding protein (CREB) phosphorylation and signaling plays an important role in long-term memory formation, but other posttranslational modifications of CREB are less known. Here, we found that CREB1Δ, the short isoform of CREB, could be sumoylated by the small ubiquitin-like modifier (SUMO) E3 ligase protein inhibitor of activated STAT1 (PIAS1) at Lys271 and Lys290 and PIAS1 SUMOylation of CREB1Δ increased the expression level of CREB1Δ.