李小媛博士
特聘研究員
Division Chief
- 02-27899125 (Lab) (Room No: 308)
- 02-27829224 (Fax)
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Specialty:
- Pathogenesis of and Neuroprotection against Alzheimer's Disease
- Molecular Mechanism of Mammalian Long-Term Memory Formation
Education and Positions:
Ph.D. Univ. of California, San Diego
Highlight Detail
CREB SUMOylation by the E3 Ligase PIAS1 Enhances Spatial Memory.
Dr. Lee, Eminy H.Y.
J. Neurosci., Jul 16, 2014cAMP-responsive element binding protein (CREB) phosphorylation and signaling plays an important role in long-term memory formation, but other posttranslational modifications of CREB are less known. Here, we found that CREB1Δ, the short isoform of CREB, could be sumoylated by the small ubiquitin-like modifier (SUMO) E3 ligase protein inhibitor of activated STAT1 (PIAS1) at Lys271 and Lys290 and PIAS1 SUMOylation of CREB1Δ increased the expression level of CREB1Δ.