Dr. Wu, Jer-Yuarn

Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans

American Journal of Human Genetics, Jan 11, 2018

Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottl ......


Dr. Lee, Te-Chang

A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Neoplasia, Dec 13, 2017

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorect ......


Dr. Shih, Hsiu-Ming

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

Scientific Reports, Dec 12, 2017

The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......


Dr. Huang, Yi-Shuian

Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival

Cell Reports, Nov 21, 2017

Summary: Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons (mainly granule cells [GCs]) to support local cir ......


Dr. Huang, Yi-Shuian

CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory

Cell Reports, Nov 14, 2017

Summary: Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting synaptic modifications and consol ......


Dr. Wu, Jer-Yuarn

A genome-wide association study links small-vessel ischemic stroke to autophagy

Scientific Reports, Nov 09, 2017

Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemi ......


Dr. Huang, Yi-Shuian

Decoding hidden messages in neurons: insights from epitranscriptome-controlled and specialized ribosome-controlled translation

Current Opinion in Neurobiology, Nov 07, 2017

Activity-regulated protein synthesis, especially in the restricted synaptic domains, is critical to maintaining connections and communicatio ......


Dr. Shih, Chiaho

Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus

Scientific Reports, Oct 31, 2017

Hepatitis B virus (HBV) is a blood-borne pathogen responsible for chronic hepatitis, cirrhosis, and liver cancer. The mechanism of HBV entry ......


Dr. Hu, Che-Ming (Jack)

Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection

ACS Applied Materials & Interfaces, Oct 31, 2017

Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ......


Dr. Hwang, Ming-Jing

A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters

Scientific Reports, Oct 27, 2017

Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of pr ......


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