2017 Highlights

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Dr. Wu , Jer-Yuarn
Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans
American Journal of Human Genetics Jan 11, 2018

Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottl ...

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Dr. Lee , Te-Chang
A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer
Neoplasia Dec 13, 2017

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorect ...

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Dr. Shih , Hsiu-Ming
Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
Scientific Reports Dec 12, 2017

The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ...

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Dr. Huang , Yi-Shuian
Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival
Cell Reports Nov 21, 2017

Summary: Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons (mainly granule cells [GCs]) to support local cir ...

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Dr. Huang , Yi-Shuian
CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory
Cell Reports Nov 14, 2017

Summary: Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting synaptic modifications and consol ...

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Dr. Wu , Jer-Yuarn
A genome-wide association study links small-vessel ischemic stroke to autophagy
Scientific Reports Nov 09, 2017

Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemi ...

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Dr. Huang , Yi-Shuian
Decoding hidden messages in neurons: insights from epitranscriptome-controlled and specialized ribosome-controlled translation
Current Opinion in Neurobiology Nov 07, 2017

Activity-regulated protein synthesis, especially in the restricted synaptic domains, is critical to maintaining connections and communicatio ...

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Dr. Shih , Chiaho
Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus
Scientific Reports Oct 31, 2017

Hepatitis B virus (HBV) is a blood-borne pathogen responsible for chronic hepatitis, cirrhosis, and liver cancer. The mechanism of HBV entry ...

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Dr. Hu , Che-Ming (Jack)
Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection
ACS Applied Materials & Interfaces Oct 31, 2017

Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ...

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Dr. Hwang , Ming-Jing
A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters
Scientific Reports Oct 27, 2017

Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of pr ...

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