2017 Highlights

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Dr. Chau , Lee-Young
Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness
Oncogene Aug 28, 2017

Overexpression of heme oxygenase-1 (HO-1), an endoplasmic reticulum-anchored enzyme, is observed in many cancers. HO-1 nuclear translocation ...

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Dr. Yan , Yu-Ting
HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity
PLoS Genetics Aug 21, 2017

HSPB7 is a member of the small heat-shock protein (HSPB) family and is expressed in the cardiomyocytes from cardiogenesis onwards. A dramati ...

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Dr. Yang , Pan-Chyr
A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect
Molecular Therapy- Nucleic Acids Aug 15, 2017

Introduction The concept of immune checkpoint blockade has revolutionized anti-cancer strategies in nearly all cancer fields.1 Monoclonal ...

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Dr. Tang , Tang K.
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
Nature Communications Aug 15, 2017

Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that ...

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Dr. Chen , Chien-Chang
Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice
Scientific Reports Aug 08, 2017

Pathological cardiac hypertrophy, a dynamic remodeling process, is a major risk factor for heart failure. Although a number of key regulator ...

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Dr. Hsieh , Patrick Ching-Ho
Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis
Scientific reports Aug 07, 2017

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn−/&minu ...

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Dr. Chern , Yijuang
Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease
Movement disorders Aug 07, 2017

Background: Disruptions in gamma-aminobutyric (GABA) acid signaling are believed to be involved in Huntington's disease pathogenesis, but th ...

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Dr. Lin , Wen-chang
A Comprehensive Analysis of Transcript-Supported De Novo Genes in Saccharomyces sensu stricto Yeasts
Molecular Biology and Evolution Jul 24, 2017

Novel genes arising from random DNA sequences (de novo genes) have been suggested to be widespread in the genomes of different organisms. Ho ...

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Dr. Liao , Fang
CCR6 Deficiency Impairs IgA Production and Dysregulates Antimicrobial Peptide Production, Altering the Intestinal Flora
Frontiers in Immunology Jul 11, 2017

Intestinal immunity exists as a complex relationship among immune cells, epithelial cells, and microbiota. CCR6 and its ligand–CCL20 a ...

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Dr. Lee , Eminy H.Y.
Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation
Frontiers in Molecular Neuroscience Jul 11, 2017

Galectin-3, a member of the galectin protein family, has been found to regulate cell proliferation, inhibit apoptosis and promote inflammato ...

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