2016 Highlights

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Dr. Hsieh , Patrick Ching-Ho
Reprogramming‐derived gene cocktail increases cardiomyocyte proliferation for heart regeneration
EMBO Molecular Medicine Dec 23, 2016

Although remnant cardiomyocytes (CMs) possess a certain degree of proliferative ability, efficiency is too low for cardiac regeneration afte ...

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Dr. Yang , Pan-Chyr
Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
Nature communications Dec 22, 2016

Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negativ ...

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Dr. Yen , Jeffrey J.Y.
Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis
Journal of Investigative Dermatology Dec 22, 2016

Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder that results from intimate interactions between genetic predispositio ...

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Dr. Hsieh , Patrick Ching-Ho
Reloadable multidrug capturing delivery system for targeted ischemic disease treatment
Science Translational Medicine Nov 16, 2016

Human clinical trials of protein therapy for ischemic diseases have shown disappointing outcomes so far, mainly because of the poor circulat ...

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Dr. Yang , Ruey-Bing (Ray)
Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis
Arteriosclerosis, Thrombosis, and Vascular Biology Nov 10, 2016

Approach and Results—SCUBE2 lentiviral overexpression in human ECs increased and short hairpin RNA knockdown inhibited VEGF-induced ...

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Dr. Tarn , Woan-Yuh
RBM4 regulates neuronal differentiation of mesenchymal stem cells by modulating alternative splicing of pyruvate kinase M
Molecular and Cellular Biology Nov 07, 2016

RBM4 promotes differentiation of neuronal progenitor cells and neurite outgrowth of cultured neurons via its role in splicing regulation. In ...

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Dr. Yang , Pan-Chyr
Remote Control of Light-Triggered Virotherapy
ACS Nano Nov 07, 2016

Clinical virotherapy has been successfully approved for use in cancer treatment by the U.S. Food and Drug Administration; however, a number ...

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Dr. Chen , Joanne Jeou-Yuan
Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner
Oncogene Nov 07, 2016

Tumor microenvironment (TME) plays an active role in promoting tumor progression. To further understand the communication between TME and tu ...

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Dr. Huang , Yi-Shuian
Deficiency of CPEB2-Confined ChAT Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction
The Journal of neuroscience Nov 03, 2016

Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is an RNA-binding protein and translational regulator. To understand the physi ...

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Dr. Lee , Yungling Leo
Growth trajectories and asthma/rhinitis in children: a longitudinal study in Taiwan
European Respiratory Journal Oct 24, 2016

Studies have reported the effect of body weight in early childhood on asthma. However, the effect of growth patterns during school age on as ...

Years