Ph.D. Case Western Research Univ.
M.D. National Taiwan University
MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor prognosis. In this study, we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic 「oncomiR」 and its role as a key mediator of EGFR signaling in lung cancer cells.