Dr. Wu, Cheng-Wen

Corresponding Research Fellow
Academician, Academia Sinica
  • 02-26523016 (Lab) (Room No: 107)
  • 02-26523075 (Fax)

  • Gene Transcription
  • Cancer Metastasis
  • Gene & Stem Cell Therapy

Education and Positions:
  • Ph.D. Case Western Research Univ.
    M.D. National Taiwan University

Lung cancer is the leading cause of death from neoplasia in the world as well as Taiwan. Lung cancer tends to metastasize very early in its course and is one of the most difficult cancers to treat. To better develop early diagnostic makers and therapeutic targets for lung cancer, we are interested in investigating the molecular mechanisms underlying lung cancer initiation, progression, and metastasis. The major research directions in our laboratory are described as follows:
  1. Deregulated EGFR signaling: Deregulated expression of EGFR together with ligand binding and concomitant receptor activation has been indicated as the key driver of lung tumorigenesis. We have discovered that deregulated EGFR signaling activates several novel transcriptional factors and microRNAs, which contribute to abnormal cell proliferation and invasions of lung cancer.
  2. Cancer stem/initiating cells: By screening molecules involved in metastasis of lung cancer cell lines, we found that several stemness factors, which maintain self-renewal and pluripotency of embryonic stem cells, are highly expressed in lung cancer. We are studying how lung cancer hijacks the embryonic stem cell program to develop metastasis and drug resistance.
We are currently addressing the diagnostic and therapeutic applications of the abovementioned studies to overcome drug resistance and metastasis, both of which will have great impact on lung cancer treatment.

  1. N.-W. Fan, T.-C. Ho, (C.-W. Wu), H.-Y. Chien, Y.-P. Tsao Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy. Exp Eye Res 2019 Aug;185:107678. doi: 10.1016/j.exer.2019.05.018. (2019-08) [JCR] [WOS]
  2. N.-W. Fan, T.-C. Ho, (C.-W. Wu), Y.-P. Tsao Pigment epithelium-derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway. J Cell Mol Med 23(7),4759-4769 (2019-07) [JCR] [WOS]
  3. Hong SY, Kao YR, Lee TC, Wu CW Upregulation of E3 Ubiquitin Ligase CBLC Enhances EGFR Dysregulation and Signaling in Lung Adenocarcinoma. Cancer research 78(17), 4984-4996 (2018-09) [JCR] [WOS]
  4. Wen KC, Sung PL, Chou YT, Pan CM, Wang PH, Lee OK, Wu CW The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma. Gynecologic oncology 148(2), 383-392 (2018) [JCR] [WOS]
  5. Wen KC, Sung PL, Hsieh SL, Chou YT, Lee OK, Wu CW, Wang PH alpha2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Oncotarget 8(17), 29013-29027 (2017) [JCR] [WOS]
  6. Hsiao SH, Chou YT, Lin SE, Hsu RC, Chung CL, Kao YR, Liu HE, Wu CW Brain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination. Oncotarget 8(32), 53405-53418 (2017) [JCR] [WOS]
  7. Lin TW, Chen MT, Lin LT, Huang PI, Lo WL, Yang YP, Lu KH, Chen YW, Chiou SH, Wu CW TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma. Oncotarget 8(34), 56612-56625 (2017) [JCR] [WOS]
  8. Lee TF, Tseng YC, Chang WC, Chen YC, Kao YR, Chou TY, Ho CC, Wu CW YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas. Oncotarget 8(52), 89539-89551 (2017) [JCR] [WOS]
  9. 1. C.-H. Hsieh, Y.-T. Chou, M.-H. Kuo, H.-P. Tsai, J.-L. Chang, C.-W. Wu A Targetable HB-EGF-CITED4 Axis Controls Oncogenesis in Lung Cancer Oncogene (2016-12) [JCR] [WOS]
  10. 2. S.-C. Lin, Y.-T. Chou, S.-S. Jiang, J.-L. Chang, C.-H. Chung, Y.-R. Kao, I.-S. Chang, C.-W. Wu WuEpigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity Cancer Research 1;76(23):7036-7048 (2016-12) [JCR] [WOS]