吳成文博士

通信研究員
中央研究院院士
  • 02-26523016 (Lab) (Room No: 107)
  • 02-26523075 (Fax)
Specialty:
  • Gene Transcription
  • Cancer Metastasis
  • Gene & Stem Cell Therapy
Education and Positions:

  • Ph.D. Case Western Research Univ.
    M.D. National Taiwan University

肺癌已成為臺灣及全球癌症死亡的首要原因，本實驗室致力於肺癌轉譯醫學的研究，我們研究的方向簡述如下：
我們發現突變的上皮生長因子受體(EGFR)在肺癌中能調控特定轉錄因子及小分子RNA(microRNA)，以導致肺癌細胞癌化。我們也發現控制胚胎幹細胞自我更新的分子在肺癌中異常表現，我們正在研究肺癌細胞如何透過對這些幹細胞分子的再啟動來達成肺癌轉移與抗藥的過程。透過對肺癌癌化分子機制的瞭解，我們也正嘗試開發新的肺癌早期診的標幟與標靶治療藥物。

期刊 106 專書 0

  1. N.-W. Fan, T.-C. Ho, (C.-W. Wu), H.-Y. Chien, Y.-P. Tsao Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy. Exp Eye Res 2019 Aug;185:107678. doi: 10.1016/j.exer.2019.05.018. (2019-08) [JCR] [WOS]
  2. N.-W. Fan, T.-C. Ho, (C.-W. Wu), Y.-P. Tsao Pigment epithelium-derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway. J Cell Mol Med 23(7),4759-4769 (2019-07) [JCR] [WOS]
  3. Hong SY, Kao YR, Lee TC, Wu CW Upregulation of E3 Ubiquitin Ligase CBLC Enhances EGFR Dysregulation and Signaling in Lung Adenocarcinoma. Cancer research 78(17), 4984-4996 (2018-09) [JCR] [WOS]
  4. Wen KC, Sung PL, Chou YT, Pan CM, Wang PH, Lee OK, Wu CW The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma. Gynecologic oncology 148(2), 383-392 (2018) [JCR] [WOS]
  5. Wen KC, Sung PL, Hsieh SL, Chou YT, Lee OK, Wu CW, Wang PH alpha2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Oncotarget 8(17), 29013-29027 (2017) [JCR] [WOS]
  6. Hsiao SH, Chou YT, Lin SE, Hsu RC, Chung CL, Kao YR, Liu HE, Wu CW Brain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination. Oncotarget 8(32), 53405-53418 (2017) [JCR] [WOS]
  7. Lin TW, Chen MT, Lin LT, Huang PI, Lo WL, Yang YP, Lu KH, Chen YW, Chiou SH, Wu CW TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma. Oncotarget 8(34), 56612-56625 (2017) [JCR] [WOS]
  8. Lee TF, Tseng YC, Chang WC, Chen YC, Kao YR, Chou TY, Ho CC, Wu CW YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas. Oncotarget 8(52), 89539-89551 (2017) [JCR] [WOS]
  9. 1. C.-H. Hsieh, Y.-T. Chou, M.-H. Kuo, H.-P. Tsai, J.-L. Chang, C.-W. Wu A Targetable HB-EGF-CITED4 Axis Controls Oncogenesis in Lung Cancer Oncogene (2016-12) [JCR] [WOS]
  10. 2. S.-C. Lin, Y.-T. Chou, S.-S. Jiang, J.-L. Chang, C.-H. Chung, Y.-R. Kao, I.-S. Chang, C.-W. Wu WuEpigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity Cancer Research 1;76(23):7036-7048 (2016-12) [JCR] [WOS]
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