2020 Highlights

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Dr. Lin , Wen-chang
Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Scientific Reports Oct 01, 2020

Abstract With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ...

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Dr. Liao , You-Di
Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant
Colloids and Surfaces B: Biointerfaces Sep 22, 2020

Abstract Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria ...

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Dr. Chen , Chih-Cheng
Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain
Annals of the Rheumatic Diseases Sep 09, 2020

Abstract Objectives: Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known tri ...

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Dr. Lee , Eminy H.Y.
Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation
Molecular Therapy Sep 05, 2020

The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ...

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Dr. Hsieh , Patrick Ching-Ho
Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank
Journal of Biomedical Science Sep 04, 2020

Abstract Background The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ...

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Dr. Lee , Yungling Leo
FUT8 remodeling of EGFR regulates epidermal keratinocyte proliferation during psoriasis development
Journal of Investigative Dermatology Sep 02, 2020

Abstract α-(1,6)-fucosyltransferase (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis i ...

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Dr. Shui , Jr-Wen
Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
Nature Communications Aug 27, 2020

Galectin-9 is a risk factor for inflammatory Crohn’s disease in the gut. Our research reveal glycosylation of lysosomal membrane prote ...

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Dr. Yang , Kai-Chien
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
Nature Communications Aug 26, 2020

Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators ...

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Dr. Yang , Pan-Chyr
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression
Cell Jul 09, 2020

Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To ...

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Dr. Lee , Yungling Leo
CEACAM3 Decreases Asthma Exacerbations and Modulates Respiratory Syncytial Virus Latent Infection in Children
Thorax Jun 30, 2020

Abstract Background: Respiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to ...

Years