2020 Highlights

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Dr. Yang , Pan-Chyr
Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein
Journal of Medicinal Chemistry Mar 26, 2020

Drug resistance has been a major threat in cancer therapies that necessitates the development of new strategies to overcome this problem. We ...

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Dr. Lim , Carmay
Sensitivity of Functional Loop Conformations on Long-Range Electrostatics: Implications for M20 Loop Dynamics in E. coli Dihydrofolate Reductase
Journal of Chemical Theory and Computation Mar 19, 2020

In E. coli dihydrofolate reductase, unusual conformational motions of a functional M20 loop that interacts with substrate and coenzyme have ...

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Dr. Hu , Che-Ming (Jack)
Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy
Nano Letters Mar 17, 2020

Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the r ...

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Dr. Li , Chia-Wei
Targeting glycosylated PD-1 induces potent anti-tumor immunity
Cancer Research Mar 10, 2020

Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a ...

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Dr. Roffler , Steve R.
Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex
ACS Nano Mar 06, 2020

Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well as in patients receiving polyethylene glycol-funct ...

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Dr. Kannagi , Reiji
BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells
Cells Feb 09, 2020

Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 dat ...

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Dr. Lin , Yi-Ling
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections
Journal of Medicinal Chemistry Feb 03, 2020

Emerging and resurging mosquito-borne flaviviruses are an important public health challenge. The increased prevalence of dengue virus (DENV) ...

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Dr. Yang , Pan-Chyr
Precision Management of Advanced Non–Small Cell Lung Cancer
Annual Review of Medicine Jan 27, 2020

The rapid evolution of treatment for advanced lung cancer is a story of how scientists have struggled to move from nonselective cytotoxic ch ...

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Dr. Lee , Eminy H.Y.
Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome
Scientific Reports Jan 23, 2020

The methyl-CpG-binding protein 2 gene, MECP2, is an X chromosome-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett s ...

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Dr. Liu , Fu-Tong
Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells
Journal of Biomedical Science Jan 15, 2020

Background Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed tha ...

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