Dr. Tarn, Woan-Yuh 's publons link picture

Dr. Tarn, Woan-Yuh

Distinguished Research Fellow
  • 02-27899015 (Lab) (Room No: N223)
  • 02-26523052
  • 02-27829142 (Fax)

Specialty:

 

  1. long non-coding RNA in DNA damage repair
  2. mRNA translation in immune surveillance
  3. alternative splicing in brain development

Education and Positions:

Ph.D. National Tsing Hua University
Postdoc Assoc. Yale University


Highlight Detail
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The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene.

Dr. Tarn, Woan-Yuh
MCB., Sep 15, 2008

Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene has a C-to-T transition at position +6 of exon 7 and thus produces exon 7-skipping mRNAs. However, we observed an unexpectedly high level of exon 7-containing SMN2 transcripts as well as SMN protein in testis of smn-/-SMN2 transgenic mice.