Dr. Tarn, Woan-Yuh 's publons link picture

Dr. Tarn, Woan-Yuh

Distinguished Research Fellow
  • 02-27899015 (Lab) (Room No: N223)
  • 02-26523052
  • 02-27829142 (Fax)



  1. mRNA splicing in neuron
  2. translational control in cancer
  3. long non-coding RNA

Education and Positions:
  • Ph.D. National Tsing Hua University
    Postdoc Assoc. Yale University

Highlight Detail

The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene.

Dr. Tarn, Woan-Yuh
MCB., Sep 15, 2008

Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene has a C-to-T transition at position +6 of exon 7 and thus produces exon 7-skipping mRNAs. However, we observed an unexpectedly high level of exon 7-containing SMN2 transcripts as well as SMN protein in testis of smn-/-SMN2 transgenic mice.