Dr. Tarn, Woan-Yuh 's publons link picture

Dr. Tarn, Woan-Yuh

Distinguished Research Fellow
  • 02-27899015 (Lab) (Room No: N223)
  • 02-26523052
  • 02-27829142 (Fax)



  1. mRNA splicing in neuron
  2. translational control in cancer
  3. long non-coding RNA

Education and Positions:
  • Ph.D. National Tsing Hua University
    Postdoc Assoc. Yale University

Post-transcriptional regulation in neuronal and cancer cells

My laboratory focuses on mRNA splicing and translation control in neuron and cancer, as well as the cellular function of lncRNAs. Alternative splicing provides a means for development- and tissue-specific gene expression. We investigate how alternative splicing programs neuronal cell differentiation and impacts brain development. The RNA binding protein RBM4 plays a role in neuronal cell differentiation and radial glial migration via alternative splicing regulation. Rbm4 knockout impaired neurotrophic signaling and hence affected cerebellar foliation. Prenatal supplementation of neurotrophin receptor agonist can rescue cerebellar development of newborn mice (submitted). RBM4 indeed regulates alternative splicing of the upstream regulators of neurotrophic signaling. In our second project, we study how RNA helicase DDX3-mediated translational control influences cancer progression. We recently reported that DDX3 promotes the translation of secretory oncogenic factors via its association with the signal recognition particle on the ER. Cancer-derived mutants of DDX3 exert higher potential to translate those pro-tumorigenic factors and hence contribute to the pro-tumorigenic microenvironment. More recently, we found that DDX3 regulates tumor immune surveillance. Therefore, inhibition of DDX3 may be an adjuvant therapy for anti-cancer treatment. In our third project, we study the role of an lncRNA in DNA double strand break (DSB) repair. We identified an lncRNA ribonucleoprotein complex containing both RNA processing and DNA repair factors. This lncRNA recruits specific ribonucleases to degrade DSB induced transcripts at DNA lesions (revised). Finally, we found that this lncRNA can co-phase separate with a RNA processing factor to form liquid-like droplets, suggesting DNA repair condensates at damage sites (revised). We would continue to unveil the importance of RNA regulation. 

Our Team
Team photo

Journal 82 Book 5

  1. Tsai YY, Shen CL, D D, Tsai CY, Tarn WY Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Communications biology 6, 910 (2023-09) [JCR] [WOS]
  2. Chia-Lin Yu, Tzu-Wei Chuang, Sabrina Yeo Samuel, Yuan-Chao Lou, and Woan-Yuh Tarn* Co-phase separation of Y14 and RNA in vitro and its implication for DNA repair RNA 29, 1-15 (2023-03) [JCR] [WOS]
  3. Tzu-Wei Chuang, Chun-Hao Su, Pei-Yu Wu, Yao-Ming Chang and Woan-Yuh Tarn* LncRNA HOTAIRM1 functions in DNA double-strand break repair via its association with DNA repair and mRNA surveillance factors NUCLEIC ACIDS RESEARCH 51, 1-19 (2023-03) [JCR] [WOS]
  4. Lai MC*, Chen YP, Li DA, Yu JS, Hung HY, Tarn WY* DDX3 interacts with USP9X and participates in deubiquitination of the anti-apoptotic protein MCL1. The FEBS journal 289, 1043-1061 (2022-02) [JCR] [WOS]
  5. Tarn, W.-Y.*, Cheng, Y., Ko, S-H., and Huang, L.-M.* Antisense oligonucleotide-based therapy of viral infections Pharmaceutics 13, 2015 (2021-11) [JCR] [WOS]
  6. Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY* The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia. iScience 24(11), 103368 (2021-10) [JCR] [WOS]
  7. Chen HH, Yu HI, Rudy R, Lim SL, Chen YF, Wu SH, Lin SC, Yang MH, Tarn WY* DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience 24(9), 103086 (2021-09) [JCR] [WOS]
  8. Tsai YY, Su CH, Tarn WY* p53 Activation in Genetic Disorders: Different Routes to the Same Destination. International journal of molecular sciences 22(17), 9307 (2021-08) [JCR] [WOS]
  9. Ko SH, Huang LM*, Tarn WY* The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection. Frontiers in microbiology 10, 2885 (2019-12) [JCR] [WOS]
  10. Chen HH, Tarn WY* uORF-mediated translational control: recently elucidated mechanisms and implications in cancer. RNA biology 16(10), 1327-1338 (2019-10) [JCR] [WOS]

Chen, Hung-Hsi
Chen, Hung-Hsi
Chuang, Tzu-Wei
Chuang, Tzu-Wei
Yu, Hsin-I
Yu, Hsin-I
Yeh, Hsin-Hong
Chang, Jason
Su, Chun-Hao
Su, Chun-Hao
Shen, Joren (Chiu-Lun)
Shen, Joren (Chiu-Lun)
Samuel, Sabrina Yeo