Dr. Lee, Te-Chang

Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links

Journal of Medicinal Chemistry, Aug 30, 2021

    Designing hybrid molecules with dual functions is one approach to improve the therapeutic efficacy of combination treatm ......

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Dr. Shen, Chen-Yang

Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study

American Journal of Cancer Research, Aug 30, 2021

The causal relationship between body mass index (BMI) and type 2 diabetes (T2D) and breast cancer prognosis is still ambiguous. The aim of t ......

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Dr. Tarn, Woan-Yuh

p53 Activation in Genetic Disorders: Different Routes to the Same Destination

International journal of molecular sciences, Aug 27, 2021

    The tumor suppressor p53 is critical for preventing neoplastic transformation and tumor progression. Inappropriate activ ......

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Dr. Huang, Yi-Shuian

Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke

Molecular Neurobiology, Aug 19, 2021

    Stroke is the leading cause of permanent disability and death in the world. The therapy for acute stroke is still limite ......

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Dr. Fann, Cathy S.-J.

Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population

Cephalalgia, Aug 18, 2021

Background The genetic substrate for headache in the general population has not been identified in Asians. We investigated suscepti ......

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Dr. Tao, Mi-Hua

Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19

PLOS Pathogens, Aug 11, 2021

    Since the pandemic of COVID-19 has intensely struck human society, small animal model for this infectious disease is in ......

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Dr. Shyue, Song-Kun

Atypical antipsychotics and CD36 pathway

Metabolism: clinical and experimental, Aug 06, 2021

    Background Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from me ......

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Dr. Hsieh, Patrick Ching-Ho

Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation

Pharmaceutics, Aug 03, 2021

Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site ......

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Dr. Mou, Yun

Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment

ACS Synthetic Biology, Aug 03, 2021

    Due to its highly immunogenic nature and the great engineerability, filamentous phage has shown promising antitumor acti ......

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Dr. Pan, Wen-Harn

Adequate protein intake in older adults in the context of frailty: cross-sectional results of the Nutrition and Health Survey in Taiwan 2014–2017

The American Journal of Clinical Nutrition, Aug 02, 2021

    Background Emerging evidence suggests that a dietary protein intake higher than the current recommended dietary all ......

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