2021 Highlights

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Dr. Chen , Chien-Chang
FAK regulates cardiomyocyte mitochondrial fission and function through Drp1
FEBS Journal Nov 05, 2021

    Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ...

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Dr. Chen , Shih-Yu
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2
Journal of Clinical Investigation Nov 01, 2021

To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to ...

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Dr. Tang , Tang K.
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum
Genes & Development Oct 28, 2021

    Joubert syndrome (JS) is a recessive ciliopathy in which all affected individuals have congenital cerebellar vermis hypo ...

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Dr. Li , Chia-Wei
Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis
American Journal of Cancer Research Oct 15, 2021

SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). ...

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Dr. Hwang , Dennis W.
A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors
Biomedicines Oct 13, 2021

We developed a new probe, Gd-DO3A-Am-PBA, for imaging tumors. Our results showed active targeting of Gd-DO3A-Am-PBA to sialic acid (SA) moie ...

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Dr. Chern , Yijuang
Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
Journal of Biomedical Science Oct 11, 2021

    In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively ...

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Dr. Chern , Yijuang
A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease Oct 08, 2021

    Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons ...

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Dr. Chen , Chih-Cheng
ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
eLife Sep 27, 2021

    CNS neurons have no sensory function, protected by the skull. For this reason, brain neuromodulation by ultrasound were ...

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Dr. Tarn , Woan-Yuh
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation
iScience Sep 24, 2021

    Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in ora ...

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Dr. Roffler , Steve R.
Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies
ACS Nano Sep 02, 2021

    Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ...

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