Dr. Chen, Chien-Chang
FAK regulates cardiomyocyte mitochondrial fission and function through Drp1
FEBS Journal, Nov 05, 2021
Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ......
Dr. Chen, Shih-Yu
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2
Journal of Clinical Investigation, Nov 01, 2021
To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to ......
Dr. Tang, Tang K.
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum
Genes & Development, Oct 28, 2021
Joubert syndrome (JS) is a recessive ciliopathy in which all affected individuals have congenital cerebellar vermis hypo ......
Dr. Li, Chia-Wei
Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis
American Journal of Cancer Research, Oct 15, 2021
SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). ......
Dr. Hwang, Dennis W.
A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors
Biomedicines, Oct 13, 2021
We developed a new probe, Gd-DO3A-Am-PBA, for imaging tumors. Our results showed active targeting of Gd-DO3A-Am-PBA to sialic acid (SA) moie ......
Dr. Chern, Yijuang
Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
Journal of Biomedical Science, Oct 11, 2021
In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively ......
Dr. Chern, Yijuang
A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, Oct 08, 2021
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons ......
Dr. Chen, Chih-Cheng
ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
eLife, Sep 27, 2021
CNS neurons have no sensory function, protected by the skull. For this reason, brain neuromodulation by ultrasound were ......
Dr. Tarn, Woan-Yuh
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation
iScience, Sep 24, 2021
Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in ora ......
Dr. Roffler, Steve R.
Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies
ACS Nano, Sep 02, 2021
Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ......