Dr. Chen, Chien-Chang

FAK regulates cardiomyocyte mitochondrial fission and function through Drp1

FEBS Journal, Nov 05, 2021

    Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ......

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Dr. Chen, Shih-Yu

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2

Journal of Clinical Investigation, Nov 01, 2021

To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to ......

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Dr. Tang, Tang K.

CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum

Genes & Development, Oct 28, 2021

    Joubert syndrome (JS) is a recessive ciliopathy in which all affected individuals have congenital cerebellar vermis hypo ......

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Dr. Li, Chia-Wei

Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis

American Journal of Cancer Research, Oct 15, 2021

SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). ......

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Dr. Hwang, Dennis W.

A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors

Biomedicines, Oct 13, 2021

We developed a new probe, Gd-DO3A-Am-PBA, for imaging tumors. Our results showed active targeting of Gd-DO3A-Am-PBA to sialic acid (SA) moie ......

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Dr. Chern, Yijuang

Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

Journal of Biomedical Science, Oct 11, 2021

    In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively ......

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Dr. Chern, Yijuang

A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Neurobiology of Disease, Oct 08, 2021

    Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons ......

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Dr. Chen, Chih-Cheng

ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

eLife, Sep 27, 2021

    CNS neurons have no sensory function, protected by the skull. For this reason, brain neuromodulation by ultrasound were ......

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Dr. Tarn, Woan-Yuh

DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

iScience, Sep 24, 2021

    Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in ora ......

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Dr. Roffler, Steve R.

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

ACS Nano, Sep 02, 2021

    Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ......

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