Cardiovascular & Metabolic Diseases

  • Elucidation of the structure/function of genes related to the normal physiology and pathophysiology of cardiovasuclar system
  • Investigation of cellular signaling and molecular mechanisms underlying the vaso-& cardioprotection and disease pathogenesis
  • Investigation of the in vivo gene functions using animal models of cardiovascular and metabolic diseases
  • Development of therapeutic approaches for cardiovascular diseases
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Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
Specialty
1. Cardiac repair and regeneration
2. Microbiota and metabolism
3. Human induced pluripotent stem cells
4. Targeted delivery of nanomedicin
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Wu, Jer-Yuarn
Research Fellow
Specialty
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine
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Yang, Ruey-Bing (Ray)
Research Fellow
Specialty

Signal transduction

Receptor biology

Vascular biology

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Shyue, Song-Kun
Associate Research Fellow
Specialty
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     
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Chen, Hung-Hsin
Assistant Research Fellow
Specialty
  1. Human Genome
  2. Genetic Epidemiology
  3. RNA-sequencing
  4. Biobank analysis
  5. Longitudinal analysis
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Lai, Shih-Lei (Ben)
Assistant Research Fellow
Specialty
  • Cardiovascular development and regeneration
  • Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
  • Developmental genetics in fish models for human diseases
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Chen, Chien-Hsiun
Research Scientist
Specialty
  • Genetic Statistics
  • Genetic Epidemiology
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Chen, Yen-Hui
Research Scientist
Specialty
  • Laboratory Animal Science
  • Mouse phenotyping
  • Cardiovascular disease
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Chang, Yi-Cheng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Diabetes and Obesity
  • Genetic epidemiology
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Cheng, Ching-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome
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Hu, Yu-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

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Yang, Kai-Chien
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Organ fibrosis and stromal biology
  • Cardiac regeneration
  • Non-coding RNA biology
  • Ion channel regulation and electrophysiology
  • Cardiac oxidative stress and arrhythmias
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Chen, Chien-Chang
Research Fellow
Cross Div.
Specialty
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease
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Hu, Che-Ming (Jack)
Associate Research Fellow
Cross Div.
Specialty

Biomaterials and Nanotechnology for Drug and Vaccine Development

Cardiovascular & Metabolic Diseases
- Research Highlights -
...
Dr. Yang , Ruey-Bing (Ray)
Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition
J Cell Sci. Nov 08, 2013

SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2) belongs to a secreted and membrane-associated multi-domain SCUBE protein family. ...

...
Dr. Shyue , Song-Kun
Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
J Biol Chem. Oct 02, 2013

Caveolin-1 (Cav-1) interacts with and mediates protein trafficking and various cellular functions. Derlin-1 is a candidate for the retrotran ...

...
Dr. Hsieh , Patrick Ching-Ho
Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice.
Nanoscale. Sep 26, 2013

Various nanoparticle (NP) properties such as shape and surface charge have been studied in an attempt to enhance the efficacy of NPs in biom ...

...
Dr. Chen , Chien-Chang
Early Growth Response 1 is an Early Signal Inducing Cav3.2 T-type Calcium Channels During Cardiac Hypertrophy.
Cardiovasc Res. Aug 08, 2013

The Cav3.2 T-channel plays a pivotal role in inducing calcineurin/nuclear factor of activated T cell (NFAT) signaling during cardiac hypertr ...

...
Dr. Chen , Chien-Chang
Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.
Mol Cell Proteomics. Jul 23, 2013

Pressure-overload stress to the heart causes pathological cardiac hypertrophy, which increases the risk of cardiac morbidity and mortality. ...

...
Dr. Hsieh , Patrick Ching-Ho
Functionalized Nanoparticles Provide Early Cardioprotection after Acute Myocardial Infarction.
J Control Release May 09, 2013

Recent developments in nanotechnology have created considerable potential toward diagnosis and cancer therapy. In contrast, the use of nanot ...

...
Dr. Hwang , Ming-Jing
LISE: a server using ligand-interacting and site-enriched protein triangles for prediction of ligand-binding sites.
Nucl. Acids Res. Apr 22, 2013

LISE is a web server for a novel method for predicting small molecule binding sites on proteins. It differs from a number of servers current ...

...
Dr. Yang , Ruey-Bing (Ray)
Zebrafish scube1 (Signal Peptide-CUB (Complement Protein C1r/C1s, Uegf, and Bmp1)-EGF (Epidermal Growth Factor) Domain-containing Protein 1) Is Involved in Primitive Hematopoiesis.
J Biol Chem. Feb 15, 2013

scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF domain-containing protein 1), the founding member of a novel sec ...

...
Dr. Hsieh , Patrick Ching-Ho
Hyaluronan Enhances Bone Marrow Cell Therapy for Myocardial Repair After Infarction.
Mol Ther. Jan 08, 2013

Hyaluronan (HA) has been shown to play an important role during early heart development and promote angiogenesis under various physiological ...

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