Ph.D., University of Illinois, Urbana-Champaign
The Cav3.2 T-channel plays a pivotal role in inducing calcineurin/nuclear factor of activated T cell (NFAT) signaling during cardiac hypertrophy. Because calcineurin/NFAT signaling is induced early after pressure overload, we hypothesized that Cav3.2 is induced by an early signal.