Dr. Chen, Chien-Chang 's orcid link picture Dr. Chen, Chien-Chang 's publons link picture

Dr. Chen, Chien-Chang

Research Fellow

Specialty:
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease

Education and Positions:
  • Ph.D., University of Illinois, Urbana-Champaign


Our laboratory focuses on the mechanisms underlying the development of persistent chronic pain using optogenetics, chemogenetics, in vivo imaging, gene targeting, electrophysiological, pharmacological and behavioral approaches in wild type and genetically modified mice.
 
Our research interests include:
 
1. To delineate the role of anterior nucleus of paraventricular thalamus (PVA) in chronic pain.  Our studies show that PVA is involved in the development and maintenance of chronic in several rodent models. We are examining the circuits through which PVA involves in chronic pain.
 
2. To understand the formation of hyperalgesia priming. Chronic pain can be initiated by one or more acute tissue insults to sensitize the neurons into the primed state; however, the mechanism underlying the priming effect is unclear. We are investigating the role of neurons and non-neuronal cells in hyperalgesia priming using acid-induced muscle pain (AIMP) model.
 
3. To investigate whether aging accelerates the development or duration of chronic pain.
Our Team
Team photo

Journal 61 Book 0

  1. Abdelaziz Mohamed Abbas, Chen Wei-Hsin, Chang Yu-Wang, Mindaye Selomon Assefa, (Chen Chien-Chang)* Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain. PNAS Nexus 3(9), 362 (2024-08-30) [JCR] [WOS]
  2. Tsai Min-Chien, Cho Rou-Ling, Lin Chin-Sheng, Jheng Yu-Sin, Lien Chih-Feng, (Chen Chien-Chang), Tzeng Bing-Hsiean Cav3.1 T-type calcium channel blocker NNC 55-0396 reduces atherosclerosis by increasing cholesterol efflux. Biochemical Pharmacology 222, 116096 (2024-04) [JCR] [WOS]
  3. Lin Chia-Yeh, Chang Yao-Ming, Tseng Hsin-Yi, Shih Yen-Ling, Yeh Hsiao-Hui, Liao You-Rou, Tang Han-Hsuan, Hsu Chia-Ling, (Chen Chien-Chang), Yan Yu-Ting, Kao Cheng-Fu Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization. Cell Reports 42(11), 113416 (2023-11) [JCR] [WOS]
  4. Chang Yu-Wang, Chen Yong-Cyuan, (Chen Chien-Chang)* Identification of Novel Targeting Sites of Calcineurin and CaMKII in Human CaV3.2 T-Type Calcium Channel. Biomedicines 11(11), 2891 (2023-10-25) [JCR] [WOS]
  5. Yeh Hsiao-hui, Chang Yao-Ming, Chang Yu-Wang, Lu Mei-Yeh Jade, Chen Yi-Hua, Lee Chia-Che, Chen Chien-Chang Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy. Journal of Molecular and Cellular Cardiology Plus 1, 100011 (2022-09) [JCR] [WOS]
  6. Suresh, P., Jasmin, S., Yen, Y., Hsu, H.J.,Varinthra, P., Pairojana, T., (Chen, C.C). and Liu, I.Y.* Attenuation of HECT-E3ligase expression rescued memorydeficits in 3xTg-AD mice. Front. Aging Neurosci. 14, 91690 (2022-07-29) [JCR] [WOS]
  7. Herzig, V.*†, Chen, Y.C.,†, Chin, Y.K.Y., Dekan, Z., Chang, Y-W, Yu, H.M., Alewood, P.F., (Chen, C.C),* and King, G.F.* The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor. biomedicines 10(5), 1066 (2022-05-04) [JCR] [WOS]
  8. Tamang, H.K., Yang, R.B., Song, Z.H., Hsu, S.C., Peng, C.C, Tung, Y.C, Tzeng, B.H.*, and (Chen, C.C.)* Cav3.2 T‐type calcium channel regulates mouse platelet activation and arterial thrombosis. Journal of Thrombosis and Haemostasis (2022-05-01) [JCR] [WOS]
  9. Chen, W.H., Lien, C.C., (Chen, C.C.)* Neuronal basis for pain- and anxiety-like behaviors in the central nucleus of the amygdala. PAIN 163(3), e463-e475 (2022-03-01) [JCR] [WOS]
  10. Hu, Y.F., Lee, A.S., Chang, S.L., Lin, S.F., Weng, C.H., Lo, H.Y., Chou, P.C., Tsai, Y.N., Sung, Y.L., (Chen, C.C.), Yang, R.B., Lin, Y.C. Kuo, T.B., Wu, C.H., Liu, J.D., Chung, T.W., & Chen, S.A. Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats.. Nature Biomedical Engineering (2021-11-22) [JCR] [WOS]

- POSTDOC -
Chang, Yu-Wang
Chang, Yu-Wang
Chen, Wei-Hsin
Chen, Wei-Hsin
- RESEARCH ASSOCIATES -
Chen, Yong-Cyuan
Chen, Yong-Cyuan
Song, Zong-Han
Song, Zong-Han
- STUDENTS -
Abdel Aziz, Mohamed Abbas Abdel Hafez
Abdel Aziz, Mohamed Abbas Abdel Hafez
Mindaye, Selomon Assefa
Mindaye, Selomon Assefa
Liang, Shao-Feng
Liang, Shao-Feng
- ALUMNI -
Cheng, Yi-Fen
Cheng, Yi-Fen
Chang, Ya-Ting
Chang, Ya-Ting
Yeh, Hsiao-Hui
Yeh, Hsiao-Hui
TAMANG, HEM KUMAR
TAMANG, HEM KUMAR