陳建璋博士
研究員
- 02-2652-3944 (Lab) (Room No: N713)
- 02-2652-3522 (Office)
- ccchen@ibms.sinica.edu.tw
Specialty:
- Chronic Pain
- Calcium Channel
- Cardiovascular Disease
Education and Positions:
Ph.D., University of Illinois, Urbana-Champaign
我們的實驗室使用光遺傳學、化學遺傳學、體內成像、基因編輯、電生理學、藥理學和行為學方法在野生型和轉殖基因小鼠中研究持續性慢性疼痛發展的潛在機制。
我們的研究興趣包括
1. 探討前室丘腦旁核 (PVA) 在慢性疼痛中的作用。我們的研究表明，PVA 參與了幾種囓齒動物模型慢性病的發展和維持。我們正在研究 PVA 如何參與慢性疼痛的神經迴路。
2. 解痛覺過敏啟動的形成。慢性疼痛可由一種或多種急性組織損傷引起，使神經元進入過敏狀態；然而，引發痛覺過敏的機制尚不清楚。我們使用酸誘導的肌肉疼痛 (AIMP) 模型，研究神經元和非神經元細胞在痛覺過敏引發中的角色。
3. 研究衰老是否會加速慢性疼痛的發展或持續時間。
Our Team
期刊 62
專書 0
期刊 62 專書 0
- Mindaye Selomon Assefa, Chen Wei-Hsin, Lin Shih-Che, Chen Yong-Cyuan, Abdelaziz Mohamed Abbas, Tzeng Yi-Shiuan, Shih Arthur Chun-Chieh, Chen Shih-Yu, Yang Shi-Bing, Chen Chien-Chang Separate anterior paraventricular thalamus projections differentially regulate sensory and affective aspects of pain. Cell Reports 43(11), 114946 (2024-11) [JCR] [WOS]
- Abdelaziz Mohamed Abbas, Chen Wei-Hsin, Chang Yu-Wang, Mindaye Selomon Assefa, (Chen Chien-Chang)* Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain. PNAS Nexus 3(9), 362 (2024-08-30) [JCR] [WOS]
- Tsai Min-Chien, Cho Rou-Ling, Lin Chin-Sheng, Jheng Yu-Sin, Lien Chih-Feng, (Chen Chien-Chang), Tzeng Bing-Hsiean Cav3.1 T-type calcium channel blocker NNC 55-0396 reduces atherosclerosis by increasing cholesterol efflux. Biochemical Pharmacology 222, 116096 (2024-04) [JCR] [WOS]
- Lin Chia-Yeh, Chang Yao-Ming, Tseng Hsin-Yi, Shih Yen-Ling, Yeh Hsiao-Hui, Liao You-Rou, Tang Han-Hsuan, Hsu Chia-Ling, (Chen Chien-Chang), Yan Yu-Ting, Kao Cheng-Fu Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization. Cell Reports 42(11), 113416 (2023-11) [JCR] [WOS]
- Chang Yu-Wang, Chen Yong-Cyuan, (Chen Chien-Chang)* Identification of Novel Targeting Sites of Calcineurin and CaMKII in Human CaV3.2 T-Type Calcium Channel. Biomedicines 11(11), 2891 (2023-10-25) [JCR] [WOS]
- Yeh Hsiao-hui, Chang Yao-Ming, Chang Yu-Wang, Lu Mei-Yeh Jade, Chen Yi-Hua, Lee Chia-Che, Chen Chien-Chang Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy. Journal of Molecular and Cellular Cardiology Plus 1, 100011 (2022-09) [JCR] [WOS]
- Suresh, P., Jasmin, S., Yen, Y., Hsu, H.J.,Varinthra, P., Pairojana, T., (Chen, C.C). and Liu, I.Y.* Attenuation of HECT-E3ligase expression rescued memorydeficits in 3xTg-AD mice. Front. Aging Neurosci. 14, 91690 (2022-07-29) [JCR] [WOS]
- Herzig, V.*†, Chen, Y.C.,†, Chin, Y.K.Y., Dekan, Z., Chang, Y-W, Yu, H.M., Alewood, P.F., (Chen, C.C),* and King, G.F.* The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor. biomedicines 10(5), 1066 (2022-05-04) [JCR] [WOS]
- Tamang, H.K., Yang, R.B., Song, Z.H., Hsu, S.C., Peng, C.C, Tung, Y.C, Tzeng, B.H.*, and (Chen, C.C.)* Cav3.2 T‐type calcium channel regulates mouse platelet activation and arterial thrombosis. Journal of Thrombosis and Haemostasis (2022-05-01) [JCR] [WOS]
- Chen, W.H., Lien, C.C., (Chen, C.C.)* Neuronal basis for pain- and anxiety-like behaviors in the central nucleus of the amygdala. PAIN 163(3), e463-e475 (2022-03-01) [JCR] [WOS]
- 博士後研究 -
張裕旺
張裕旺
- Tel: 26523944
- E-mail:
國立陽明大學
國際研究生分子醫學學程
自我介紹(目前的職業狀況)Using mass spectrometry-based proteomics and phoshoproteomics to study the disease mechanism in animal; Identification and regulation of phosphorylation of T-type calcium channel; Role of dynamin-related protein Drp1 in animal model of disease.
陳瑋鑫
陳瑋鑫
- Tel: 26523944
- E-mail:
國立中興大學
生物科技學研究所
自我介紹(目前的職業狀況)My project focus on how acute pain transit to chronic pain by acid-induced muscle pain model. We find that the activation of PKC/ERK signal pathway and downstream mTOR pathway dependent protein synthesis is required for acute pain transition to chronic pain.
- 研究助理 -
- 學生 -
莫罕
莫罕
- Tel: 26523944
- E-mail:
國立成功大學
Taiwan International Graduate Program Interdisciplinary Neuroscience (TIGP-INS)
閔思洛
閔思洛
- Tel: 26523944
- E-mail:
國立成功大學
Taiwan International Graduate Program Interdisciplinary Neuroscience (TIGP-INS)
梁紹峯
梁紹峯
- Tel: 26523944
- E-mail:
PhD candidate, Graduate Program of Translational Medicine, Tzu Chi University and Academic Sinica, Taiwan
- 昔日夥伴 -
鄭義奮
鄭義奮
- Tel: 27871248
- E-mail:
國防醫學院
生命科學研究所
自我介紹(目前的職業狀況)Postdoctoral researcher at Genomic Research Center, Academia SINICA
張雅婷
張雅婷
- Tel: 26523944
- E-mail:
國立陽明大學
國際研究生分子醫學學程
自我介紹(目前的職業狀況)The central machenism of chronic pain using mouse model. My focus is studying the function of a brain region, PVA, in pain circuitry: how PVA neurons response to noxious peripheral imputs, how it mediates chronic pain developement. Hopefully this will be a step to the better pain management.
葉筱慧
葉筱慧
- Tel: 26523944
- E-mail:
國立陽明大學
國際研究生分子醫學學程
自我介紹(目前的職業狀況)My study interest is in the field of cardiac hypertrophy. Cardiac hypertrophy can be classified by the cardiac function, causes and molecular mechanism into two categories: physiological and pathological cardiac hypertrophy. For example, the fetal gene reprograming is a distinct feature of pathological cardiac hypertrophy; however, we find those fetal genes, such as atrial natriuretic factor (ANF), β-myosin heavy chain (β-MHC), are not expressed on every cardiomyocyte in the pathological hypertrophic heart. I desire to know what makes cardiomyocytes from a single heart have different phenotype. Taking advantage of the transgenic mouse line which can express yellow fluorescent protein (YFP) tagged β-MHC fusion protein, I am trying to analyze the gene or protein expression pattern to characterize the YFP positive and negative cardiomyocytes. I am using transverse aortic banding (TAB) and neurohumoral infusion to induce pathological cardiac hypertrophy in YFP-β-MHC transgenic mice. Meanwhile, I will use several approaches and techniques, such as fluorescence activated cell sorting (FACS), next generation sequencing (NGS), immunofluorescence assay, western blot and qPCR to analyze the gene/protein expression. This study can help us to understand more mechanism in cellular level, and hopefully may help us to discover a better way to treat the cardiovascular disease.
沈翰
沈翰
- Tel: 26523944
國立陽明大學
國際研究生分子醫學學程
自我介紹(目前的職業狀況)Platelets play important role in hemostasis and thrombus formation. Increased intracellular calcium concentration leads to activation of platelets followed by aggregation. Previous studies have shown that elevation in [Ca2+]I occurs through the release of ca2+ from intracellular stores and entry of extracellular ca2+ from different calcium channels. However, role of T type calcium channel in platelets activation is not yet known. Preliminary study involving FeCl3 induced carotid artery thrombosis showed lesser thrombosis in Cav3.2 (KO) mice compared to wild type and Cav3.1. Therefore, we hypothesize that T type calcium channel, especially Cav3.2, is present in platelets and somehow influences either adhesion, activation or aggregation of platelets.