Dr. Shyue, Song-Kun
Associate Research Fellow
- 02-27899153 (Lab) (Room No: N337)
- 02-26523962 (Office)
- 02-27829224 (Fax)
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Specialty:
- Caveolin-1
- Protein Degradation
- PGs & Cardiovascular Diseases
- Adenovirus vector gene therapy
Education and Positions:
Ph.D. Univ. of Texas-Houston, Health Science Center
Highlight Detail
Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
Dr. Shyue, Song-Kun
J Biol Chem., Oct 02, 2013Caveolin-1 (Cav-1) interacts with and mediates protein trafficking and various cellular functions. Derlin-1 is a candidate for the retrotranslocation channel of endoplasmic reticulum proteins. However, little is known about how Derlin-1 mediates glycosylated protein degradation. Here, we identified Cav-1 as a key player in Derlin-1- and p97-mediated cyclooxygenase 2 (COX-2) ubiquitination and degradation.