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徐松錕博士

長聘副研究員
  • 02-27899153 (Lab) (Room No: N337)
  • 02-26523962 (Office)
  • 02-27829224 (Fax)

Specialty:
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     

Education and Positions:
  • Ph.D. Univ. of Texas-Houston, Health Science Center


Highlight Detail
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Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.

Dr. Shyue, Song-Kun
J Biol Chem., Oct 02, 2013

Caveolin-1 (Cav-1) interacts with and mediates protein trafficking and various cellular functions. Derlin-1 is a candidate for the retrotranslocation channel of endoplasmic reticulum proteins. However, little is known about how Derlin-1 mediates glycosylated protein degradation. Here, we identified Cav-1 as a key player in Derlin-1- and p97-mediated cyclooxygenase 2 (COX-2) ubiquitination and degradation.