Dr. Tai, Jung-Hsiang 's publons link picture

戴榮湘博士

兼任研究員
Specialty:
  • Molecular Biology
Education and Positions:

  • Ph.D. Michigan State University

本室研究著重於人類陰道滴蟲的轉錄調控與訊息傳遞。我們以建立的好的模式研究受鐵調節轉錄的分子機制；利用這個系統模式，已找到和不同Myb轉錄因子作用的起動子位置。Myb轉錄因子包括活化轉錄的Myb2和Myb3，以及抑制轉錄的Myb1；它們顯然在不同細胞層面協力調控受鐵誘導基因ap65-1的轉錄。近來利用分子生物學，細胞生物學，和蛋白質體學的方法，下列各項的細胞機制已漸漸明白： 1) Myb1, Myb2和Myb3進入細胞核的調節；2) Myb3穩定性的調節；3)鐵引發的訊息傳遞。未來的研究重點在探討鐵和過氧化氫所引發的訊息傳遞與基因表現，瞭解陰道滴蟲在宿主環境中面對的挑戰。
Our Team
Team photo

期刊 31 專書 0

  1. Hong-Ming Hsu, Yu-Hsin Huang, Sarita Aryal, Hsing-Wei Liu, Chinpan Chen, Shu-Hui Chen, Chien-Hsin Chu* & Jung-Hsiang Tai* Endomembrane protein trafficking regulated by a TvCyP2 cyclophilin in the protozoan parasite, Trichomonas vaginalis. SCIENTIFIC REPORTS 10(1),1275 (2020-01) [JCR] [WOS]
  2. Martin, T., Lou, Y. C., Chou, C.C., Wei, SY, Sadotra, S. Cho, CC, Lin, MH, Tai, J. H., Hsu, CH, and Chen C. Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis SCIENTIFIC REPORTS 8, 5410 (2018-04) [JCR] [WOS]
  3. Chu CH, Huang YH, Liu HW, Hsu HM, Tai JH Membrane localization of a Myb3 transcription factor regulated by a TvCyP1 cyclophilin in the parasitic protozoan Trichomonas vaginalis The FEBS Journal 285(5), 929-946 (2018-01-11) [JCR] [WOS]
  4. Ku, M. C., Fang, C. M., Cheng, J. T., Liang, H. C., Wang, T. F., Wu, C. H., Chen, C. C., Tai, J. H., Chen, S. H. Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes SCIENTIFIC REPORTS 6:28804 (2016-06) [JCR] [WOS]
  5. Arroyo R, Ochoa T, Tai JH, de la Garza M Iron and Parasites. Biomed Research International 2015, 291672 (2015) [JCR] [WOS]
  6. Hsu, H. M., Lee, Y., Liu, H. W., Chu, C. H., Chen, Y. R., Chen, S. H., Hsu, P. H., and J. H. Tai Signal transduction triggered by iron to induce the nuclear translocation of a Myb3 transcription factor in the protozoan parasite, Trichomonas vaginalis. Journal of Biological Chemistry 289, 29334-29349 (2014-11) [JCR] [WOS]
  7. Hsu, H. M., Chu, C. H., Wang, Y. T., Lee, Y., Wei, S. Y., Liu, H. W., Ong, S. J., Chen, C., and J. H. Tai*. Regulation of nuclear translocation of the Myb1 transcription factor by TvCyclophilin 1 in the protozoan parasite, Trichomonas vaginalis. JOURNAL OF BIOLOGICAL CHEMISTRY 289(27), 19120-19136 (2014-07) [JCR] [WOS]
  8. Wei SY, YC Lou, JY Tsai, MR Ho, M Rajasekaran, HM Hsu, (JH Tai), YC Liaw, and TH Huang Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal b-hairpin conformation. NUCLEIC ACIDS RESEARCH 40(1), 449-460 (2012-01) [JCR] [WOS]
  9. Hsu, H. M., Lee, Y., Indra, D., Wei, S. Y., Liu, H. S., Chang, L. C., Chen, C., Ong, S. J. and J.H. Tai.* Iron-inducible nuclear translocation of a Myb3 transcription factor in the protozoan parasite Trichomonas vaginalis. EUKARYOTIC CELL 11(12), 1441-1450 (2012) [JCR] [WOS]
  10. Chu CH, LC Chang, HM Hsu, SY Wei, HW Liu, Y Lee, CC Kuo, C Chen, SJ Ong and (JH Tai)* A highly organized structure mediating nuclear localization of a Myb2 transcription factor in the protozoan parasite Trichomonas vaginalis. EUKARYOTIC CELL 10, 1607-1617 (2011-10) [JCR] [WOS]
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