林小喬博士
退休研究員
- +886-2-2789-9043 (Lab) (Room No: N117)
- +886-2-2652-3031 (Office)
- +886-2-2788-7641 (Fax)
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Specialty:
- Computational Biophysics
- Computational Chemistry
- Bioinformatics
Education and Positions:
1984, Ph.D. in Chemical Physics, University of Minnesota, Minneapolis
1979, B.S. in Chemistry, Royal Holloway College, London University
本實驗室長期的研究思維與主題是：(1)闡明控制生物化學過程的物理-化學準則；(2)用這些準則來找出新標的與幫助藥物設計；(3)發展研究巨分子的新方法。我們目前的研究著重在以下三個領城：
1. 蛋白質辨識：系統性的研究各種關鍵因子在蛋白質-輔因子，蛋白質-蛋白質，及蛋白質-核酸之間如何決定親和力及專一性。
2. 循理性藥物設計：從第1點求得的準則將應用在(a)找出新的藥物標的與(b)引導設計出有用或具治療性質的分子。
3. 新演算法與理論：我們正在發展新的方法來輔助分析巨分子的結構與功能。
我們使用的計算方法包含ab initio量子力學方法、量子力學/分子力學混合技術、分子動力學/自由能模擬、連續介電質方法、溶劑化理論、蛋白質對接、同源性模擬法、資料庫探勘與多變量統計方法。以上在生物資訊、計算物理學與計算化學方面的研究將包括對生物學、物理學、化學與資訊科學的深入探討，因此學生可以發展各學科間的知識與專業技術。
Our Team
期刊 155
專書 1
期刊 155 專書 1
- Karen Sargsyan*, Karine Mazmanian*, (Carmay Lim)* A 2023: to small molecule drugs and application to SARS-CoV-2. SCIENTIFIC REPORTS 13, 502 (2023) [JCR] [WOS]
- Sahana Shankar, Zi-Ting Hsu, Artur Ezquerra, Chien-Chien Li, Tzu-Lun Huang, Etienne Coyaud, Cédric Grauffel, Brian Raught, Carmay Lim, Jens Lüders*, Su-Yi Tsai*, and Kuo-Chiang Hsia* A g-tubulin complex-dependent pathway suppresses unscheduled ciliogenensis by promoting cilia disassembly. Cell Reports 41, 111642 (2022-11-15) [JCR] [WOS]
- Cédric Grauffel*, Wei-Hsiang Weng, (Carmay Lim*) Factors Allowing Small Monovalent Li+ to Displace Ca2+ in Proteins. Phys. Chem. Chem. Phys. 24, 17759 (2022-07-05) [JCR] [WOS]
- Wen-Hao Tsai (蔡文豪), Cédric Grauffel, Ming-Yueh Huang (黃名鉞), Sandra Postić, Marjan Slak Rupnik, Carmay Lim (林小喬), Shi-Bing Yang (楊世斌)* Allosteric coupling between TM4 and selectivity filter regulates extracellular pH gating of TALK1 potassium channels. J. Biol.Chem. 298, 101998 (2022-04-29) [JCR] [WOS]
- Ting Chen, Cédric Grauffel, Wei-Zen Yang, Yi-Ping Chen, Hanna S. Yuan* and (Carmay Lim*) Efficient strategy to design protease inhibitors: Application to enterovirus 71 2A protease. ACS Bio & Med Chem Au 4, 437-449 (2022-04-19) [JCR] [WOS]
- Karine Mazmanian, Ting Chen, Karen Sargsyan, & Carmay Lim* From quantum-derived principles underlying cysteine reactivity to combating the COVID-19 pandemic. WIRES Computational Molecular Science 12, e1607 (2022-02-13) [JCR] [WOS]
- Yao Chi Chen*, Yu-Hsien Chen, Jon D. Wright, and (Carmay Lim*) PPI-HotspotDB: Database of Protein!Protein Interaction Hot Spots. J. Chem. Inf. Model. 62, 1052-1060 (2022-02-11) [JCR] [WOS]
- Todor Dudev,* Cedric Grauffel,* and (Carmay Lim*) Calcium in signaling: Its specificity and vulnerabilities towards biogenic and abiogenic metal ions.. The Journal of Physical Chemistry B 125,37, 10419-10431 (2021-09) [JCR] [WOS]
- Cédric Grauffel*, Wei-Hsiang Weng, Todor Dudev,(Carmay Lim*) The trinuclear calcium site in the C2 domain of PKCα/γis prone to lithium attack.. ACS Omega 6,31, 20657-20666 (2021-07) [JCR] [WOS]
- Babu C. Satheesan, Lim Carmay Influence of solution ionic strength on the stabilities of M20 loop conformations in apo E. coli dihydrofolate reductase. The Journal of Chemical Physics 154(19), 195103 (2021-05) [JCR] [WOS]
- 博士後研究 -
- E-mail:
Ph.D. in Chemistry,
University of Hyderabad,
India
- E-mail:
Ph.D. in Chemistry and Biochemistry,
University of Essex,
U.K., 1996
- E-mail:
Ph.D. in Chemistry,
University of Strasbourg,
France, 2009
李育銘
李育銘
- E-mail:
Ph.D. in Chemistry,
National Tsing Hua
University, Taiwan, 2010
陳婷
陳婷
- E-mail:
Ph. D. in Life Sciences,
National Tsing Hua University,
Taiwan, 2010
陳耀琦
陳耀琦
- E-mail:
Ph. D. in Chemistry,
National Tsing Hua University,
Taiwan
- 研究助理 -
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1979 |
Arnold Spicer Prize (for Best B.Sc. Candidate) from London University |
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1980 |
3M Foundation Fellowship |
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1981 |
National Science Foundation Fellowship, USA |
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1982 |
University of Minnesota Doctoral Dissertation Fellowship |
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1995-2000 |
National Science Council Scientist Award (國科會研究獎) |
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2000-2002 |
National Science Council Outstanding Scientist Award (國科會傑出 研究獎) |
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2003-2008 |
Foundation for the Advancement of Outstanding Scholarship Outstanding Scholar Award (傑出人才基金會講座) - one of the 2 recipients awarded in 2003 in all fields; recipients cannot receive any other awards during the award period. |
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2004 |
The Chinese Chemical Society Annual Best Article Award 中國化學 會會誌論文獎 |
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2007-2011 |
Academia Sinica Investigator Award (中央研究院深耕計畫) |
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2008-2011 |
Human Frontier Science Program (HFSP) Research Award |
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2009 |
Ministry of Education 53rd Academic Award (教育部學術獎) |
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2009/08-2012/07 |
National Science Council Outstanding Scientist Award (國科會傑出 研究獎) |
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2013-2022 |
Academia Sinica Investigator Award (中央研究院深耕計畫) |