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陳儀莊博士

所長
特聘研究員
  • +886227899028 (Lab) (Room No: N333)
  • +886226523913 (Office)
  • 02-27829143 (Fax)

Specialty:
  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease

Education and Positions:
  • Ph.D. Univ. of Massachusetts


我們有兩個研究主題:(1)腺苷A2A受體(adenosine A2A receptor; A2AR)的功能, 及(2)開發神經退化疾病(包括亨丁頓舞蹈症,漸凍人症,和阿茨海默症)的新穎藥物。

      咖啡因是世界上使用最廣泛的精神活化物質,其藥理上的作用目標就是A2AR。我們研究室多年前找到A2AR的基因,近年則研究A2AR在神經退化疾​​病中的病理功能,調控機轉,和訊號轉導。以神經退化疾病的小鼠模型,我們對於導致神經退化的病理機制也進行深入研究,藉著找到新穎的疾病機轉(例如,神經發炎,異常 GABA 信號),來設計更好的治療方法。

      此外,我們開發了一組可同時調控A2AR 和腺苷轉運蛋白1 (ENT1) 的腺苷藥物。這些化合物可以進入大腦來調控腺苷濃度,可治療至少五種蛋白質聚集疾病(包括 HD、ALS、SCA3、SCA7、AD 和 Niemann-Pick C)。這些化合物也已獲得未來應用於神經退化疾​​病治療方法的專利保護。

Our Team
Team photo

期刊 138 專書 4

  1. Chang Y-C, Tsai Y-C, Chang E-C, Hsu Y-C, Huang Y-R, Lee Y-H, Tsai Y-S, Chen Y-Q, Lee Y-C, Liao Y-C, Kuo J-C, Su M-T, Yang UCξ, (Chern Y)*, Cheng T-H* Altered PIAS1, UBC9, and ATXN3 Interactions by PIAS1 S510G Variant Selectively Reduce Mutant ATXN3.. The International Journal of Biochemistry & Cell Biology 176, 106662 (2024-11) [JCR] [WOS]
  2. Liu Y-J, Lee C-W, Liao Y-C, Huang J J-T, Kkuo H-C, Jih K-Y, Lee Y-C, (Chern Y)* The role of adiponectin-AMPK axis in TDP-43 mislocalization and disease severity in ALS.. Neurobiology of Disease 202, 106715 (2024-10-28) [JCR] [WOS]
  3. Chang C-P, Wu C-W, (Chern Y)* Metabolic Dysregulation in Huntington\'s Disease: Neuronal and Glial Perspectives.. Neurobiology of Disease 201, 106672 (2024-10-15) [JCR] [WOS]
  4. Lu Y-S, Hung W-C, Hsieh Y-T, Tsaai P-Y, Tsai T-H, Fan H-H, Chang Y-G, Cheng H-K, Huang S-Y, Lin H-C, Lee Y-H, Shen T-H, Hung B-Y, Tsai J-W, Dzhagalov I, Cheng I H-J, Lin C-J, (Chern Y), Hsu C-L* Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington's disease in the mouse model. Brain Behavior and Immunity 120, 413-429 (2024-06-24) [JCR] [WOS]
  5. Siew JJ, Chen H-M, Chiu F-L, Lee C-W, Chang Y-M, Chen H-L, Nguyen TNA, Liao H-T, Liu M, Hagar H-T, Sun Y-C, Lai H-L, Kuo M-H, Blum D, Buee L, Jin L-W, Chen S-Y, Ko T-M, Huang J-r, Kuo H-C, Liu F-T, Chern Y* Galectin-3 aggravates microglial activation and tau transmission in tauopathy. JOURNAL OF CLINICAL INVESTIGATION 134(2), e165523 (2024-01-16) [JCR] [WOS]
  6. Ho S-Y, Chen I-C, Tsai C-W, Chang K-C, Lin C-J, Chern Y, Liou H-H* Anticonvulsant effect of equilibrative nucleoside transporters 1 inhibitor in a mouse model of Dravet syndrome. HIPPOCAMPUS 34(1), 7-13 (2023-11-06) [JCR] [WOS]
  7. Siew Jian Jing, Chern Yijuang, Khoo Kay-Hooi, Angata Takashi Roles of Siglecs in neurodegenerative diseases. Molecular Aspects of Medicine 90, 101141 (2023-04) [JCR] [WOS]
  8. Weng YT, Chang YM, (Chern Y)* The Impact of Dysregulated microRNA Biogenesis Machinery and microRNA Sorting on Neurodegenerative Diseases.. International Journal of Molecular Sciences 24, 3443 (2023-02-08) [JCR] [WOS]
  9. Chen Ching-Ya, Chou Fang-Yi, Chang Ya-Gin, Ho Chin-Jui, Wu Kuo-Chen, Hsu Chia-Lin, Chern Yijuang, Lin Chun-Jung Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington\'s disease. Neurobiology of Disease 177, 106004 (2023-02) [JCR] [WOS]
  10. Chen Kuan-Yu, Lu Chiao-Shin, Pang Cheng-Yoong, Ho Chin-Jui, Wu Kuo-Chen, Yang Hsiu-Wei, Lai Hsin-Lin, Chern Yijuang, Lin Chun-Jung Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury. Molecular Neurobiology 60(1), 369-381 (2023-01) [JCR] [WOS]

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Lee, Yan-Hua
李晏嬅
Lin, Hsin-Chuan
林心荃
Lin, Chien-Yu
林建宇
Liu, Yu-Ju
劉育儒
Chang, Ching-Pang
張敬邦
Siew, Jian-Jing
蕭建靖
Weng, Yu-Ting
翁于婷
- 研究助理 -
Lai, Hsing-Lin
賴幸琳
Chen, Huei-Mei
陳惠美
Lin, Todd
林冠宇
Wu,  Ching-Wen
吳靖雯
Lee, Willy
李家維
Pei-Rong, Chang
張沛容
member
呂懿庭
- 學生 -
NG, HIN FUNG JOSH
吳興灃
Hsu, TengYang
許騰陽
Chan, Yee-Lam
陳以琳
Chang, Pi-Hsiang
張弼翔
Claire, Chuang
莊嬿臻
Chang, Ya-Gin
張雅晶
- 昔日夥伴 -
Lin, Yow-Sien
林佑憲
Chou, Szu-Yi
周思怡
Wu, Yi-Chih
吳宜之
Lee, Chien-Fei
李建飛
Ju, Tz-Chuen
朱自淳
Hsiao, Han-Yun
蕭涵云
Sun, Chung-Nan
孫忠男
Wang, Jiz-Yuh
王志煜
Chien, Chen-Li
簡禎利
Chen, Yu-Chen
陳昱辰
Lee, Li-Ming
李俐旻
Wu, Tse Hsiang
吳澤祥
NGUYEN, THI NGOC ANH
阮氏玉英
Wu, Yi-Ting
吳宜庭
Huang, Haoning
黃皞甯
He, Chih Lin
何志麟
Lee, Chia-Chia
李珈嘉
Jen, Wei-Ping
任蔚平
Wu, Yu-Shuo
吳育碩
Chien, Ting
簡莛
Lai, Jia-You
賴佳攸
Lin, Meng-Syuan
林孟璇
Hsu, Yi-Ting
許怡婷
Tsai, Andy Po-Yi
蔡伯宜