Dr. Chern, Yijuang 's publons link picture Dr. Chern, Yijuang 's Youtube

陳儀莊博士

所長
特聘研究員
  • +886227899028 (Lab) (Room No: N333)
  • +886226523913 (Office)
  • 02-27829143 (Fax)
Specialty:
  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease
Education and Positions:

  • Ph.D. Univ. of Massachusetts

我們有兩個研究主題：（1）腺苷A2A受體（adenosine A2A receptor; A2AR）的功能, 及（2）開發神經退化疾病（包括亨丁頓舞蹈症，漸凍人症，和阿茨海默症）的新穎藥物。

      咖啡因是世界上使用最廣泛的精神活化物質，其藥理上的作用目標就是A2AR。我們研究室多年前找到A2AR的基因，近年則研究A2AR在神經退化疾​​病中的病理功能，調控機轉，和訊號轉導。以神經退化疾病的小鼠模型，我們對於導致神經退化的病理機制也進行深入研究，藉著找到新穎的疾病機轉（例如，神經發炎，異常 GABA 信號），來設計更好的治療方法。

      此外，我們開發了一組可同時調控A2AR 和腺苷轉運蛋白1 (ENT1) 的腺苷藥物。這些化合物可以進入大腦來調控腺苷濃度，可治療至少五種蛋白質聚集疾病（包括 HD、ALS、SCA3、SCA7、AD 和 Niemann-Pick C）。這些化合物也已獲得未來應用於神經退化疾​​病治療方法的專利保護。

Our Team
Team photo

期刊 133 專書 4

  1. 1.Siew JJ, Chen H-M, Chiu F-L, Lee C-W, Chang Y-M, Chen H-L, Nguyen TNA, Liao H-T, Liu M, Hagar H-T, Sun Y-C, Lai H-L, Kuo M-H, Blum D, Buee L, Jin L-W, Chen S-Y, Ko T-M, Huang J-r, Kuo H-C, Liu F-T, Chern Y* Galectin-3 aggravates microglial activation and tau transmission in tauopathy. JOURNAL OF CLINICAL INVESTIGATION (2023-11-21) [JCR] [WOS]
  2. Ho S-Y, Chen I-C, Tsai C-W, Chang K-C, Lin C-J, Chern Y, Liou H-H* Anticonvulsant effect of equilibrative nucleoside transporters 1 inhibitor in a mouse model of Dravet syndrome. HIPPOCAMPUS 34(1), 7-13 (2023-11-06) [JCR] [WOS]
  3. Siew Jian Jing, Chern Yijuang, Khoo Kay-Hooi, Angata Takashi Roles of Siglecs in neurodegenerative diseases. Molecular Aspects of Medicine 90, 101141 (2023-04) [JCR] [WOS]
  4. Chen Ching-Ya, Chou Fang-Yi, Chang Ya-Gin, Ho Chin-Jui, Wu Kuo-Chen, Hsu Chia-Lin, Chern Yijuang, Lin Chun-Jung Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington\'s disease. Neurobiology of Disease 177, 106004 (2023-02) [JCR] [WOS]
  5. Chen Kuan-Yu, Lu Chiao-Shin, Pang Cheng-Yoong, Ho Chin-Jui, Wu Kuo-Chen, Yang Hsiu-Wei, Lai Hsin-Lin, Chern Yijuang, Lin Chun-Jung Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury. Molecular Neurobiology 60(1), 369-381 (2023-01) [JCR] [WOS]
  6. Lee Yan Hua, Lee Yi‐Chung, Tsai Yu‐Shuen, Yang Ueng‐Cheng, Cheng Tzu‐Hao, Chern Yijuang, Soong Bing‐Wen Reply to: “Low Frequency of p.S510G in PIAS1 Challenges Its Relevance for Modifying Repeat Expansion Disorders”. Movement Disorders 37(10), 2169-2169 (2022-10-17) [JCR] [WOS]
  7. Yu-Ting Weng, Hui-Mei Chen, Ting Chien, Feng-Lan Chiu, Hung-Chih Kuo, (Yijuang Chern)* TRAX Provides Neuroprotection for Huntington\'s Disease Via Modulating a Novel Subset of MicroRNAs. Movement Disorders 37(10), 2008-2020 (2022-10-17) [JCR] [WOS]
  8. Wang Lee-Hsin, Lin Chien-Yu, Lin Yu-Mei, Buée Luc, Sergeant Nicolas, Blum David, Chern Yijuang, Wang Guey-Shin Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration. The Journal of Neuroscience 42(25), 5102-5114 (2022-05-23) [JCR] [WOS]
  9. Peyton L, Leon B, Essa H, Chern Y, Choi DS N$^6$-Substituated Adenosine Analog J4 Attenuates Anxiety-like Behaviors in Mice. PSYCHOPHARMACOLOGY 239, 887-895 (2022-01-31) [JCR] [WOS]
  10. Yan Hua Lee, BSc, Yu-Shuen Tsai, Che-Chang Chang, Chun-Chen Ho, Hsiu-Ming Shih, Hui-Mei Chen, Hsing-Lin Lai, Chia-Wei Lee, Yi-Chung Lee, Yi-Chu Liao, Ueng-Cheng Yang, Tzu-Hao Cheng, Yijuang Chern, and Bing-Wen Soong, A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis. MOVEMENT DISORDERS 10.1002/mds.28896, 1-12 (2021-12) [JCR] [WOS]
- More Publications-

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李晏嬅
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林心荃
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林建宇
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劉育儒
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張敬邦
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蕭建靖
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翁于婷
- 研究助理 -
Lai, Hsing-Lin
賴幸琳
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陳惠美
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林冠宇
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吳靖雯
Lee, Willy
李家維
Pei-Rong, Chang
張沛容
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呂懿庭
He, Chih Lin
何志麟
- 學生 -
NG, HIN FUNG JOSH
吳興灃
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許騰陽
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陳以琳
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張弼翔
Claire, Chuang
莊嬿臻
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張雅晶
- 昔日夥伴 -
Lin, Yow-Sien
林佑憲
Chou, Szu-Yi
周思怡
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吳宜之
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李建飛
Ju, Tz-Chuen
朱自淳
Hsiao, Han-Yun
蕭涵云
Sun, Chung-Nan
孫忠男
Wang, Jiz-Yuh
王志煜
Chien, Chen-Li
簡禎利
Chen, Yu-Chen
陳昱辰
Lee, Li-Ming
李俐旻
Wu, Tse Hsiang
吳澤祥
NGUYEN, THI NGOC ANH
阮氏玉英
Wu, Yi-Ting
吳宜庭
Huang, Haoning
黃皞甯
Lee, Chia-Chia
李珈嘉
Jen, Wei-Ping
任蔚平
Wu, Yu-Shuo
吳育碩
Chien, Ting
簡莛
Lai, Jia-You
賴佳攸
Lin, Meng-Syuan
林孟璇
Hsu, Yi-Ting
許怡婷
Tsai, Andy Po-Yi
蔡伯宜