Dr. Lin, Jung-Hsin 's publons link picture

林榮信博士

合聘研究員
  • 26523993 (IBMS) (Lab) (Room No: 234)
  • (02) 2787-3143 (RCAS)
  • (02) 2787-3122 (Fax)
Specialty:
  • Pharmacoinformatics
  • Computational Biophysics
Education and Positions:

  • Ph.D., University of Duisburg, Germany

本實驗室主要在發展並應用計算及模擬方法以探討生物分子間的交互作用，尤其著重探討分子的動態變化，並以高效能計算提供X-ray 與NMR 等結構生物實驗未有的資訊，藉以進行較新穎的藥物設計。此外，本實驗室也提供天然物與已在市場上的藥物在過去未知的作用標的之預測，例如在2007年時我們成功地預測了降血脂藥物statins其實也是抗癌標的HDAC的抑制劑。 除了與藥物設計直接相關的研究課題以外，近來本實驗室也運用分子動力學模擬探討分子馬達的作用機制、端粒(telomere)所形成的新穎Quadruplex結構的動態變化、及細胞膜運輸蛋白次分子層級的運作機制等課題。

Our Team
Team photo

期刊 68 專書 5

  1. Daniel Förster, Jérôme Idier, Leo Liberti, Antonio Mucherino, (Jung-Hsin Lin) and Thérèse E. Malliavin Low-resolution description of the conformational space for intrinsically disordered proteins SCIENTIFIC REPORTS 12, 19057-19057 (2022-11-9) [JCR] [WOS]
  2. Dhananjay C. Joshi, Charlie Gosse, Shu-Yu Huang and (Jung-Hsin Lin*) A curvilinear-path umbrella sampling approach to characterizing the interactions between rapamycin and three FKBP12 variants FRONTIERS IN MOLECULAR BIOSCIENCES 9, 879000-879000 (2022-07-08) [JCR] [WOS]
  3. Wei Lim Chonga, Visit Vao-soongnern, Piyarat Nimmanpipug, Chatchai Tayapiwatana, (Jung-Hsin Lin,) Yi-Ling Lin, Hui Yee Cheeg, Sharifuddin Md Zain Molecular dynamics simulations and Gaussian network model for designing antibody mimicking protein towards dengue envelope protein JOURNAL OF MOLECULAR LIQUIDS 346, 118086-118086 (2022-01-15) [JCR] [WOS]
  4. Antonio Mucherino, Douglas Gonçalves, Leo Liberti, (Jung-Hsin Lin*), Carlile Lavor, Nelson Maculan MD-jeep: a New Release for Discretizable Distance Geometry Problems with Interval Data Annals of Computer Science and Information Systems 21, 289-294 (2020-10) [JCR] [WOS]
  5. Chen, CT, Liao, LZ, Lu, CH,Huang, YH, Lin, YK, (Lin, JH),Chow, LP Quantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells EXPERIMENTAL AND MOLECULAR MEDICINE 52(3), 497-513 (2020-03) [JCR] [WOS]
  6. Jung-Hsin Lin Dynamics of Melttin Pores in Liposomes Probed by All-Atom Simulations Biophysical Society Meeting 382 (2020-02) [JCR] [WOS]
  7. Dhananjay C. Joshi and (Jung-Hsin Lin) Investigating the Role of Interfacial Waters in Protein-Protein Recognition Mechanism Biophysical Society Meeting 503 (2020-02) [JCR] [WOS]
  8. Joshi Dhananjay C., (Lin Jung‐Hsin*) Delineating Protein–Protein Curvilinear Dissociation Pathways and Energetics with Naïve Multiple‐Walker Umbrella Sampling Simulations Journal of Computational Chemistry 40(17) 1652-1663 (2019-06) [JCR] [WOS]
  9. Mucherino Antonio*, (Lin Jung-Hsin*), Gonçalves Douglas S. A Coarse-Grained Representation for Discretizable Distance Geometry with Interval Data Bioinformatics and Biomedical Engineering 3-13 (2019) [JCR] [WOS]
  10. Mucherino Antonio, (Lin Jung-Hsin*) An Efficient Exhaustive Search for the Discretizable Distance Geometry Problem with Interval Data Proceedings of the 2019 Federated Conference on Computer Science and Information Systems 18, 135-141 (2019) [JCR] [WOS]
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