Dr. Liao, You-Di 's publons link picture

廖有地博士

兼任研究員
  • 2652-3053 (Office)
Specialty:
  • Protein Chemistry
  • Antitumor Ribonucleases
  • Antimicrobial Protein/Peptides
Education and Positions:

  • Ph.D. National Taiwan University

1. 牛蛙之RNA 水解酵素群具抗癌特性，本實驗室以基因突變，核磁共振及X光繞射法，研究其抗癌機制及生化特性。

 

2. RNA 水解酵素及陽離子抗菌胜肽扮演宿主防禦重要的角色，本實驗室發現其參與破壞細菌外膜的胺基酸，進而找到其在細菌外膜之標的蛋白質，藉此研究抗菌機轉及篩選抗菌胜肽，以克服抗藥菌株產生的問題。

 

3. 甲硫胺酸(Met)為蛋白質合成之起始胺基酸，但常會影響蛋白質之功能及穩定性，我們改造了大腸桿菌之甲硫胺酸去除酶，應用於大腸桿菌表現重組蛋白質，可去除蛋白質N端的甲硫胺酸。

Our Team
Team photo

期刊 40 專書 0

  1. Tang WH, Wang SH, Wang CF, Mou Y, Lin MG, Hsiao CD, Liao YD The lipid components of high-density lipoproteins (HDL) are essential for the binding and transportation of antimicrobial peptides in human serum. Scientific reports 12(1), 2576 (2022) [JCR] [WOS]
  2. Jung CJ, Liao YD, Hsu CC, Huang TY, Chuang YC, Chen JW, Kuo YM, Chia JS Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia. Scientific reports 11(1), 7318 (2021) [JCR] [WOS]
  3. Tang Wen-Hung, Wang Chiu-Feng, Liao You-Di Fetal bovine serum albumin inhibits antimicrobial peptide activity and binds drug only in complex with α1-antitrypsin Scientific Reports 11(1) ,1267 (2021) [JCR] [WOS]
  4. Wang Shih-Han, Tang Tony Wen-Hung, Wu Eden, Wang Dan-Wei, Liao You-Di Anionic Surfactant-Facilitated Coating of Antimicrobial Peptide and Antibiotic Reduces Biomaterial-Associated Infection ACS Biomaterials Science & Engineering 6(8), 4561-4572 (2020) [JCR] [WOS]
  5. Wang Shih-Han, Tang Tony Wen-Hung, Wu Eden, Wang Dan-Wei, Wang Chiu-Feng, Liao You-Di Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant Colloids and Surfaces B: Biointerfaces 196, 111364 (2020) [JCR] [WOS]
  6. Wang SH, Wang CF, Chang TW, Wang YJ, Liao YD Oligomerization and insertion of antimicrobial peptide TP4 on bacterial membrane and membrane-mimicking surfactant sarkosyl. PloS one 14(5), e0216946 (2019-05) [JCR] [WOS]
  7. Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PloS one 12(10), e0186442 (2017) [JCR] [WOS]
  8. Wei HM, Lin LC, Wang CF, Lee YJ, Chen YT, Liao YD Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin. PloS one 11(6), e0156321 (2016) [JCR] [WOS]
  9. Tseng TS, Wang SH, Chang TW, Wei HM, Wang YJ, Tsai KC, Liao YD, Chen C Sarkosyl-Induced Helical Structure of an Antimicrobial Peptide GW-Q6 Plays an Essential Role in the Binding of Surface Receptor OprI in Pseudomonas aeruginosa. PloS one 11(10), e0164597 (2016) [JCR] [WOS]
  10. Lin CH, Chen JK, Ko TM, Wei CY, Wu JY, Chung WH, Chen SY, Liao YD, Hung SI, Chen YT Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction. The Journal of allergy and clinical immunology 135(4), 1063-1065.e5 (2015) [JCR] [WOS]
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