Dr. Chau, Lee-Young

Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology, Nov 05, 2020

Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......

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Dr. Kwok, Pui-Yan

Towards a reference genome that captures global genetic diversity

Nature Communications, Oct 30, 2020

Abstract The current human reference genome is predominantly derived from a single individual and it does not adequately reflect human ......

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Dr. Huang, Yi-Shuian

CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling

Cell Reports, Oct 20, 2020

Summary Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. ......

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Dr. Liu, Fu-Tong

Galectin‐7 downregulation in lesional keratinocytes contributes to enhanced IL‐17A signaling and skin pathology in psoriasis

Journal of clinical investigation, Oct 15, 2020

Abstract Psoriasis is a chronic inflammatory skin disease characterized by inflammatory cell infiltration, as well as hyperproliferatio ......

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Dr. Lin, Wen-chang

Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset

Scientific Reports, Oct 01, 2020

Abstract With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......

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Dr. Liao, You-Di

Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant

Colloids and Surfaces B: Biointerfaces, Sep 22, 2020

Abstract Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria ......

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Dr. Chen, Chih-Cheng

Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain

Annals of the Rheumatic Diseases, Sep 09, 2020

Abstract Objectives: Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known tri ......

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Dr. Lee, Eminy H.Y.

Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation

Molecular Therapy, Sep 05, 2020

The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ......

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Dr. Hsieh, Patrick Ching-Ho

Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank

Journal of Biomedical Science, Sep 04, 2020

Abstract Background The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ......

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Dr. Lee, Yungling Leo

FUT8 remodeling of EGFR regulates epidermal keratinocyte proliferation during psoriasis development

Journal of Investigative Dermatology, Sep 02, 2020

Abstract α-(1,6)-fucosyltransferase (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis i ......

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