Dr. Lim, Carmay

Free and Bound Therapeutic Lithium in Brain Signaling

Accounts of Chemical Research, Sep 26, 2019

Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this begu ......

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Dr. Lin, Wen-chang

Overlapping protein-coding genes in human genome and their coincidental expression in tissues

Scientific Reports, Sep 16, 2019

The completion of human genome sequences and the advancement of next-generation sequencing technologies have engendered a clear understandin ......

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Dr. Chern, Yijuang

Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors

Translational Psychiatry, Aug 27, 2019

Sialic acids are typically added to the end of glycoconjugates by sialyltransferases. Among the six ST8 α-N-acetyl-neuraminide α ......

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Dr. Hsieh, Patrick Ching-Ho

Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction

Theranostics, Aug 21, 2019

Rationale: Long non-coding RNA (lncRNAs) has been identified as a pivotal novel regulators in cardiac development as well as cardiac pathoge ......

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Dr. Lee, Yungling Leo

Assessing Causality Between Childhood Adiposity and Early Puberty: A Bidirectional Mendelian Randomization and Longitudinal Study

Metabolism, Aug 15, 2019

Aims Obesity and early puberty have been reported to be mutually causative. We investigated the causal relationship between adiposity a ......

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Dr. Pan, Wen-Harn

Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese?

Journal of Clinical Medicine, Aug 12, 2019

Background: Serum uric acid (SUA) has gradually been recognized as a potential risk factor for cardiovascular disease (CVD). However, whethe ......

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Dr. Hsieh, Patrick Ching-Ho

MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction

EBioMedicine, Aug 07, 2019

Background Myocardial infarction (MI) is a life-threatening disease, often leading to heart failure. Defining therapeutic targets at an ......

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Dr. Lee, Yungling Leo

Early Pubertal Maturation and Risk of Childhood Asthma: A Mendelian Randomization and Longitudinal Study

Allergy, Aug 06, 2019

BACKGROUND: Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this ......

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Dr. Yang, Pan-Chyr

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin

European Journal of Medicinal Chemistry, Aug 02, 2019

Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we ......

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Dr. Chern, Yijuang

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Nature Communications, Aug 02, 2019

Huntington’s disease (HD) is a neurodegenerative disorder that manifests with movement dysfunction. The expression of mutant Huntingti ......

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