Dr. Pan, Wen-Harn

Individualized home-based exercise and nutrition interventions improve frailty in older adults: a randomized controlled trial

International Journal of Behavioral Nutrition and Physical Activity, Dec 02, 2019

Background Frail older adults are predisposed to multiple comorbidities and adverse events. Recent interventional studies have shown that ......

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Dr. Shen, Chen-Yang

The Causal Relationship of Circulating Triglycerides and Glycated Hemoglobin: A Mendelian Randomization Study

Journal of Clinical Endocrinology & Metabolism, Nov 30, 2019

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Dr. Lim, Carmay

Why Cellular Di/Triphosphates Preferably Bind Mg2+ and Not Ca2+

Journal of Chemical Theory and Computation, Nov 27, 2019

Di/triphosphates perform a multitude of essential tasks, being important components of many vital organic cofactors such as adenosine/guanos ......

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Dr. Pan, Wen-Harn

The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components

International Journal of Obesity, Nov 21, 2019

Background/objectives Hyperuricemia has been found to cluster with multiple components of metabolic syndrome (MetS). It is unclear whethe ......

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Dr. Shih, Chiaho

Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Journal of Biomedical Science, Nov 11, 2019

Background Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV- ......

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Dr. Shih, Chiaho

Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model

Journal of Virology, Oct 29, 2019

Hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations in natural infection. Wild-type HBV is known to secrete predominan ......

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Dr. Hsieh, Patrick Ching-Ho

Human iPSC banking: barriers and opportunities

Journal of Biomedical Science, Oct 28, 2019

The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new op ......

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Dr. Yen, Jeffrey J.Y.

Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADi3 and TGM1 protein stability

Journal of Investigative Dermatology, Oct 25, 2019

Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier permeability and renders mice susceptible to environmental bac ......

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Dr. Chang, Ya-Jen

Pulmonary IL‐33 orchestrates innate immune cells to mediate RSV‐evoked airway hyperreactivity and eosinophilia

Allergy, Oct 17, 2019

Background Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 is elevated a ......

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Dr. Lim, Carmay

Free and Bound Therapeutic Lithium in Brain Signaling

Accounts of Chemical Research, Sep 26, 2019

Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this begu ......

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