Dr. Lee, Yungling Leo

CEACAM3 Decreases Asthma Exacerbations and Modulates Respiratory Syncytial Virus Latent Infection in Children

Thorax, Jun 30, 2020

Abstract Background: Respiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to ......

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Dr. Jou, Yuh-Shan

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, Jun 18, 2020

Abstract Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......

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Dr. Liu, Fu-Tong

Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)

Journal of Biomedical Science, Jun 04, 2020

On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of ......

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Dr. Yang, Pan-Chyr

Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer

Journal of Controlled Release, Jun 01, 2020

Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which char ......

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Dr. Lim, Carmay

How the Local Environment of Functional Sites Regulates Protein Function

Journal of the American Chemical Society, May 19, 2020

Abstract Proteins form complex biological machineries whose functions in the cell are highly regulated at both the cellular and mol ......

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Dr. Roffler, Steve R.

Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes

Acta Biomaterialia, May 15, 2020

Abstract Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the a ......

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Dr. Shen, Chen-Yang

Tumorigenic and Metastatic Role of CD44−/low/CD24−/low Cells in Luminal Breast Cancer

Cancers, May 14, 2020

Abstract Cells with high CD44 but low CD24 expression (CD44high/CD24-/low) and high aldehyde dehydrogenase activity (ALDHbr) are widely ......

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Dr. Lin, Yi-Ling

Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice

PLOS Pathogens, May 11, 2020

Abstract Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregna ......

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Dr. Huang, Yi-Shuian

CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis

Journal of Biomedical Science, Apr 15, 2020

Background Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic ......

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Dr. Yang, Pan-Chyr

Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein

Journal of Medicinal Chemistry, Mar 26, 2020

Drug resistance has been a major threat in cancer therapies that necessitates the development of new strategies to overcome this problem. We ......

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